72867-29-9Relevant academic research and scientific papers
Synthesis and characterization of Pd supported on methane diamine (propyl silane) functionalized Fe3O4 nanoparticles as a magnetic catalyst for synthesis of α-aminonitriles and 2-methoxy-2-phenylacetonitrile derivative via Strecker-t
Li, Qun,Liu, Wei,Mohammadnia, Majid,Song, Di,Sun, Mingzhe,Wu, Wei,Yan, Li
, (2021/09/18)
Pd supported on methane diamine (propyl silane) functionalized Fe3O4 magnetic nanoparticles as an organic–inorganic hybrid heterogeneous catalyst was fabricated and characterized by FT-IR, XRD, SEM, TEM, TGA, VSM, EDX, and ICP-AES te
Nitrile compound catalytic synthesis method and application thereof
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Paragraph 0109-0115; 0139-0150; 0154, (2021/07/01)
The invention relates to the technical field of chemical catalytic synthesis, and particularly discloses a nitrile compound catalytic synthesis method and application thereof. According to the nitrile compound catalytic synthesis method, an alpha-aminonitrile or alpha-imino nitrile compound can be synthesized through selective reaction. The nitrile compound catalytic synthesis method has the advantages of simple and easily available raw materials, wide substrate applicability, mild conditions, high yield and the like, the yield is superior to that of a traditional chemical synthesis method, and the nitrile compound catalytic synthesis method is suitable for industrial production. The problems that an existing synthesis method of alpha-aminonitrile and alpha-imino nitrile compounds is not high in yield and does not meet the requirement of green chemistry are solved. Moreover, compared with a traditional chemical synthesis method, a heme system is more efficient and green in use, a substrate is simple and easy to obtain, a tedious catalysis step is not needed, a low-toxicity cyano donor is used, the substrate is wide in applicability, the requirement of green chemistry is met, and the heme system has a wide market prospect.
KF/clinoptilolite nanoparticles as an efficient nanocatalyst for the Strecker synthesis of α-aminonitriles
Khalilzadeh, Mohammad A.,Oladee, Razieh,Zareyee, Daryoush
, (2020/05/04)
Abstract: Potassium fluoride impregnated on clinoptilolite nanoparticles (KF/CP NPs) have been explored to serve as an effective and inexpensive heterogeneous catalyst for the one-pot three-component Strecker synthesis of a variety of α-aminonitriles at room temperature in ethanol as a green solvent. KF/CP NPs have been synthesized using simple impregnation techniques in aqueous media from readily available inexpensive starting materials and displayed its initial catalytic activity even after five runs. The easy preparation and separation of catalyst, simple procedure, mild reaction conditions, and excellent yields of products render this method as an attractive sustainable option. Graphic abstract: [Figure not available: see fulltext.]
Triggering Lewis Acidic Nature through the Variation of Coordination Environment of Cd-Centers in 2D-Coordination Polymers
Kumar, Nikhil,Paul, Avijit Kumar
supporting information, p. 1284 - 1294 (2020/02/04)
The rational design and successful synthesis of novel functional metal-organic frameworks relies on careful selection of metals and versatile organic ligands. A newly designed pyrazole-based dicarboxylate ligand, 5-(3,5-dimethyl-1H-pyrazol-1-yl) 1,3-benze
Three-component solventless Strecker synthesis of α-aminonitriles catalysed by a renewable sulfonated nanoporous carbon catalyst (CMK-5-SO3H)
Zareyee, Daryoush,Rad, Ali Shokuhi,Ataei, Zahra,Javadi, Sayed Hossein,Khalilzadeh, Mohammad A.
, (2018/07/31)
The one-pot three-component synthesis of a variety of α-aminonitriles has been studied using a catalytic amount of a sulfonic acid-functionalized ordered nanoporous carbon catalyst, CMK-5-SO3H, at room temperature under solvent-free reaction co
Synthesis of imidazolidin-2-ones employing dialkyl carbonates as an ecofriendly carbonylation source
Badru, Rahul,Singh, Baldev
, p. 38978 - 38985 (2014/11/07)
A new approach to the synthesis of imidazolidin-2-ones by carbonylation of vicinal diamines with dialkyl carbonates using Pb(NO3)2 and Cu(ii) salts as catalysts has been described in the present protocol. A comparative study using Cu(ii) salts and Pb(NO3)2 as catalysts has suggested Cu(NO3)2 and CuCl 2·2H2O salts to be as promising as Pb(NO 3)2 and can replace the latter in the carbonylation reactions employing dialkyl carbonates. the Partner Organisations 2014.
Sulfamic acid-functionalized magnetic Fe3O4 nanoparticles as an efficient and reusable catalyst for one-pot synthesis of α-amino nitriles in water
Kassaee,Masrouri, Hassan,Movahedi, Farnaz
experimental part, p. 28 - 33 (2012/01/04)
Grafting of chlorosulfuric acid on the amino-functionalized Fe 3O4 nanoparticles afforded sulfamic acid-functionalized magnetic Fe3O4 nanoparticles (SA-MNPs) as a novel organic-inorganic hybrid heterogeneous catalyst, which was characterized by XRD, FT-IR, TGA, TEM, and elemental analysis. The catalytic activity of SA-MNPs was probed through one-pot synthesis of α-amino nitriles via three-component couplings of aldehydes (or ketones), amines and trimethylsilyl cyanide in water, at room temperature. The heterogeneous catalyst could be recovered easily and reused many times without significant loss of its catalytic activity.
Convenient and rapid synthesis of α-aminonitriles starting directly from nitro compounds in water
Das, Biswanath,Satyalakshmi, Gandham,Suneel, Kanaparthy
experimental part, p. 2770 - 2773 (2009/09/25)
A distinct approach for the synthesis of α-aminonitriles has been discovered by three-component reaction of nitroarenes, aldehydes, and TMSCN using indium in dilute aqueous HCl at room temperature. The products were formed in high yields (86-96%) within a
One-pot synthesis of α-aminonitriles using a highly efficient and recyclable silica-based scandium (III) interphase catalyst
Karimi, Babak,Safari, Ali Asghar
, p. 2967 - 2970 (2008/12/22)
Both aryl and alkyl imines, which formed in situ from aldehydes and amines undergo smooth nucleophilic addition with trimethylsilyl cyanide in the presence of a catalytic amount of a silica-based scandium (III) interphase catalyst under mild reaction condition to furnish the corresponding α-aminonitriles in good to excellent yields. The catalyst shows high thermal stability (up to 300 °C) and it could also be recovered and reused for at least 6 reaction cycles without considerable lose of its reactivity.
Synthetic Uses of Open-Chain Analogues of Reissert Compounds
McEwen, William E.,Grossi, Anthony V.,MacDonald, Russell J.,Stamegna, Andrew P.
, p. 1301 - 1308 (2007/10/02)
Open-chain analogues, 2, of Reissert compounds are readily obtained by reaction of cyanohydrins with primary amines, the resulting aminonitriles, 1, then being acylated.Hydrofluoroborate salts, 3, of 2 are prepared by reaction with fluoroboric acid in glacial acetic acid.The salts, 3, undergo 1,3-dipolar addition reactions with reactive alkynes to give substituted pyrroles and with ethyl acrylate to give a different type of substituted pyrrole, the initial step in this instance being a Diels-Alder reaction.The open-chain Reissert analogues 2 also undergo base-catalyzed reactions, such as alkylation to provide compounds 22, which, in turn, undergo cleavage reactions in ethanolic alkali to give ketones 23.A conjugate addition reaction of the anion 18 to methyl acrylate to give, after some subsequent steps, a substituted pyrrole, 9, has also been demonstrated. α-Anilino ketones 27 result when the anion 18 is caused to react with aldehydes, the initial reaction mixtures being subjected to subsequent alkaline hydrolysis.Finally, N-benzyl Reissert analogues have been found to give desoxybenzoins plus benzonitriles on treatment with sodium hydride in tetrahydrofuran.
