72869-16-0 Usage
Description
Pramiracetam sulfate, together with aniracetam are two nootropics of the piracetam
family introduced in 1993 for the treatment of attention and memory disorders resulting from
degenerative or vascular disorders in the elderly. In patients with mild to moderate primary
degenerative dementia, treatment with 75-300 mg/day of pramiracetam reduced depression,anxiety, sleep disturbance, and hostility with no observable adverse reactions. Significant
improvement of performance on measures of memory, especially delayed recall, have been
observed for pramiracetam treated patients with brain injury.
Originator
Warner-Lambert (U.S.A.)
Uses
Different sources of media describe the Uses of 72869-16-0 differently. You can refer to the following data:
1. Pramiracetam Sulfate is a nootropic and a cognition activator drug. It also increases the rate of learning of complex visual discrimination problems in young, normal rhesus monkeys.
2. Cognition adjuvant.
Brand name
Remen; Neupramir;
Prarnistar
Check Digit Verification of cas no
The CAS Registry Mumber 72869-16-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,8,6 and 9 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 72869-16:
(7*7)+(6*2)+(5*8)+(4*6)+(3*9)+(2*1)+(1*6)=160
160 % 10 = 0
So 72869-16-0 is a valid CAS Registry Number.
72869-16-0Relevant articles and documents
Industrial preparation method of pramiracetam sulfate
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Paragraph 0035; 0052; 0057; 0058; 0059; 0064; 0065; 0070, (2020/04/02)
The invention relates to the field of preparation of compounds, in particular to an industrial preparation method of pramiracetam sulfate. The method includes: (1) converting N-(2-(diisopropyl)ethyl)-2-chloroacetamide hydrochloride to obtain free amide, and removing moisture in the free amide; (2) reacting solid alkali with alpha-pyrrolidone in a solvent I under the protection of nitrogen, simultaneously distilling alcohol generated by the reaction, then adding a solution prepared from the free amide and the solvent I dropwise, and carrying out reaction to obtain pramiracetam; and (3) preparing pramiracetam and sulfuric acid into pramiracetam sulfate. According to the method, pramiracetam sulfate with excellent quality can be efficiently obtained, and the method has the characteristics oflow cost, high environmental friendliness, no use of dangerous materials, and high process safety, and is beneficial to popularization and application in industrial preparation.
