72874-41-0

Basic information

• Product Name: 8-methylthio-1-[(dimethylamino)methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine
• Synonyms: 8-methylthio-1-[(dimethylamino)methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine
• CAS NO: 72874-41-0
• Molecular Weight: 363.486
• Mol File: 72874-41-0.mol

Chemical Properties

• CAS DataBase Reference: 8-methylthio-1-[(dimethylamino)methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine(CAS DataBase Reference)
• NIST Chemistry Reference: 8-methylthio-1-[(dimethylamino)methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine(72874-41-0)
• EPA Substance Registry System: 8-methylthio-1-[(dimethylamino)methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine(72874-41-0)

Safety Data

• Hazardous Substances Data: 72874-41-0(Hazardous Substances Data)

Upstream product

• 55-85-6 N-amino-2-(dimethylamino)acetamide 
• 35628-45-6 1,3-dihydro-7-(methylthio)-5-phenyl-2H-1,4-benzodiazepine-2-thione 
• 5725-96-2 N,N-dimethylhydroxylamine 

Relevant articles and documents

1-(Aminoalkyl)-6-aryl;-4H-s-triazole[4,3-a][1,4]benzodiazepines with antianxiety and antidepressant activity

A series of 1-(Aminoalkyl)-6-aryl;-4H-s-triazole[4,3-a][1,4]benzodiazepines has been prepared and evaluated for central nervous system activity. The authors have found that members of this series have activity in pharmacological test systems designed to detect both anxiolytic and antidepressant activity. Each type of activity could be varied independently by appropriate substituent selections.

1-[(Aminooxy)-methyl]-6-substituted-4H-s-triazolo[4,3-a][1,4] benzodiazepines

Compounds of the formula: STR1 wherein R'o and R"o are hydrogen or alkyl of 1 to 3 carbon atoms, inclusive; R1 is hydrogen, fluoro, chloro, bromo, nitro, trifluoromethyl, or alkylthio in which the alkyl moiety is of 1 to 3 carbon atoms, inclusive; R2 is phenyl, o-chlorophenyl, 0-fluorophenyl, 2,6-difluorophenyl and 2-pyridyl are prepared by multistep reactions from compounds of formula I: STR2 wherein R1 and R2 are defined as above and X is chlorine or bromine. Compounds of formula III, intermediates in the preparation thereof, Schiff's bases of compounds IIIA (III in which R'o and R"o are hydrogen), and the pharmacologically acceptable acid addition salts are useful in birds and mammals, including man, as sedatives, antianxiety, antidepressant, anticonvulsive, and muscular relaxing agents.