5725-96-2Relevant articles and documents
Method for coproducing vasoxine hydrochloride and N,O-dimethylhydroxylamine hydrochloride
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Paragraph 0042-0048, (2017/04/03)
The invention relates to the technical field of compound synthesis methods, particularly a method for coproducing vasoxine hydrochloride and N,O-dimethylhydroxylamine hydrochloride. The method comprises the following steps: carrying out methylation reaction on hydroxylamine salt under alkaline conditions by using a methylating agent to obtain a reaction solution containing vasoxine and N,O-dimethylhydroxylamine, rectifying to separate a vasoxine bottom solution and an N,O-dimethylhydroxylamine crude distillate, respectively adding hydrochloric acid for salification, concentrating and crystallizing under reduced pressure, cooling, carrying out vacuum filtration, recrystallizing with water or methanol, and drying to obtain the vasoxine hydrochloride product and N,O-dimethylhydroxylamine hydrochloride product. The method has the advantages of simple and reliable technique, high product quality, high total yield and low comprehensive cost, and is more friendly to the environment and suitable for industrial production.
METHODS FOR CONVERSION OF TYROSINE TO P-HYDROXYSTYRENE AND P-HYDROXYCINNAMIC ACID
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Page/Page column 7, (2008/12/06)
Three different reaction steps were combined to provide methods for preparing p-hydroxystyrene and p-hydroxycinnamic acid monomers from tyrosine. The three steps include reductive alkylation of tyrosine, followed by oxidation to the N-oxide, and thermal Cope elimination. During Cope elimination, either p-hydroxycinnamic acid or p-hydroxystyrene was produced depending on the absence or presence of base, respectively. Additionally, p-acetoxystyrene may be prepared by reacting the prepared p-hydroxystyrene either directly or after isolation with an acetylating agent.
An antibody-catalyzed [2,3]-elimination reaction
Yoon, Seung Soo,Oei, Yoko,Sweet, Elizabeth,Schultz, Peter G.
, p. 11686 - 11687 (2007/10/03)
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