7288-34-8Relevant academic research and scientific papers
Conformational behaviour of hydroxamic acids: Ab initio and structural studies
Brown, David A.,Coogan, Raymond A.,Fitzpatrick, Noel J.,Glass, William K.,Abukshima, Dau E.,Shiels, Loreto,Ahlgren, Markku,Smolander, Kimmo,Pakkanen, Tuula T.,Pakkanen, Tapani A.,Peraekylae, Mikael
, p. 2673 - 2679 (2007/10/03)
The conformational behaviour of a series of monohydroxamic acids, p-RC6H4CONR 'OH (R = Me, R' = H Me; R = MeO, R' = H, Me; R = NO2, R' = H), and a series of dihydroxamic acids, (CH2)n (CONR'OH)2 (n = 3-8, 10, R' = H and n = 7, R' = Me), in methanol, DMSO and chloroform and in the solid state has been examined using IR and NMR spectroscopy. X-Ray crystal structure determinations of p-MeC6H4CONMeOH and the monohydrate of glutarodihydroxamic acid (n = 3) together with ab initio molecular orbital calculations for several hydrated and unhydrated hydroxamic acids have been performed. Hydrogen bonding effects are shown to be important in both the so id state and solution. The cis(Z) conformation of the hydroxamate group(s) (CONHOH) is preferentially stabilized by hydrogen bonding with water molecules.
A FACILE SYNTHESIS OF ALIPHATIC DIHYDROXAMIC ACIDS OF GENERAL FORMULA RONR'-CO-(CH2)n-CO-NR'OR
Brown, D. A.,Geraty, R. A.,Glennon, J. D.,Choileain, N. Ni
, p. 1159 - 1164 (2007/10/02)
Synthesis of dihydroxamic acids using dicarboxylic acids and N,N'-carbonyldiimidazole.
