728895-76-9

Upstream product

• 135042-17-0 (2R,4S)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 
• 728895-62-3 (2R,4S)-2-(1-Acetoxy-allyl)-4-triisopropylsilanyloxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 728896-03-5 (2R,4S)-2-(1-Hydroxy-allyl)-4-triisopropylsilanyloxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 728895-66-7 Acetic acid 1-((2R,4S)-1-acryloyl-4-triisopropylsilanyloxy-pyrrolidin-2-yl)-allyl ester 
• 728895-97-4 (2R,4S)-4-Triisopropylsilanyloxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 
• 728896-00-2 (2R,4S)-2-Hydroxymethyl-4-triisopropylsilanyloxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 728895-69-0 Acetic acid (2S,8aR)-5-oxo-2-triisopropylsilanyloxy-1,2,3,5,8,8a-hexahydro-indolizin-8-yl ester 
• 728895-58-7 (2R,4S)-2-Formyl-4-triisopropylsilanyloxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 728895-73-6 (2S,8S,8aR)-8-Hydroxy-2-triisopropylsilanyloxy-2,3,8,8a-tetrahydro-1H-indolizin-5-one 
• 728896-05-7 3-Vinyl-benzoic acid (2S,8S,8aR)-5-oxo-2-triisopropylsilanyloxy-1,2,3,5,8,8a-hexahydro-indolizin-8-yl ester 

Downstream Products

• 728895-82-7 3-Vinyl-benzoic acid (2S,8S,8aR)-2-((2R,3S)-3-allyloxycarbonylamino-5-methyl-2-triisopropylsilanyloxy-hex-4-enoyloxy)-5-oxo-1,2,3,5,8,8a-hexahydro-indolizin-8-yl ester 

Relevant academic research and scientific papers

Design and synthesis of de novo cytotoxic alkaloids through mimicking taxoid skeleton

Based on a common pharmacophore model and the hypothesis that the baccatin core of taxoids is a scaffold securing the proper orientation of the side chains, a bicyclic alkaloid scaffold was designed as a baccatin surrogate. Using this scaffold, two novel