728895-82-7Relevant academic research and scientific papers
Design and synthesis of de novo cytotoxic alkaloids through mimicking taxoid skeleton
Geng, Xudong,Geney, Raphael,Pera, Paula,Bernacki, Ralph J.,Ojima, Iwao
, p. 3491 - 3494 (2007/10/03)
Based on a common pharmacophore model and the hypothesis that the baccatin core of taxoids is a scaffold securing the proper orientation of the side chains, a bicyclic alkaloid scaffold was designed as a baccatin surrogate. Using this scaffold, two novel
