728919-99-1

Basic information

• Product Name: 4-TERT-BUTYLBENZYLISOCYANIDE
• Synonyms: 1-TERT-BUTYL-4-(ISOCYANOMETHYL)BENZENE;4-TERT-BUTYLBENZYLISOCYANIDE
• CAS NO: 728919-99-1
• Molecular Formula: C₁₂H₁₅N
• Molecular Weight: 173.25
• Mol File: 728919-99-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-TERT-BUTYLBENZYLISOCYANIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-TERT-BUTYLBENZYLISOCYANIDE(728919-99-1)
• EPA Substance Registry System: 4-TERT-BUTYLBENZYLISOCYANIDE(728919-99-1)

Safety Data

• Hazardous Substances Data: 728919-99-1(Hazardous Substances Data)

Usage

General Description

4-Tert-butylbenzylisocyanide is a chemical compound with the molecular formula C12H15N. It is a yellowish to brown colored liquid, and is insoluble in water. It is commonly used as a reagent and intermediate in organic synthesis, and is known for its ability to form various types of compounds, particularly when reacted with different types of organic molecules. 4-Tert-butylbenzylisocyanide is also used in the preparation of various pharmaceuticals and agrochemicals. It is important to handle this chemical with proper caution and under controlled conditions due to its potential health and safety hazards.

InChI:InChI=1/C12H15N/c1-12(2,3)11-7-5-10(6-8-11)9-13-4/h5-8H,9H2,1-3H3

Upstream product

• 939-97-9 4-tert-Butylbenzaldehyde 
• 7677-24-9 trimethylsilyl cyanide 
• 18880-00-7 1-(bromomethyl)-4-(1,1-dimethylethyl)benzene 
• 19692-45-6 4-tert-butylbenzyl chloride 
• 877-65-6 p-tert-butylbenzyl alcohol 

Downstream Products

• 1178564-05-0 C₂₄H₃₁N₃O₃ 
• 1178564-04-9 C₃₀H₃₆ClN₃O₃ 
• 1178564-02-7 C₂₆H₃₅N₃O₃ 
• 1178564-03-8 C₂₆H₃₅N₃O₃ 
• 1187828-75-6 C₁₆H₂₁NO 
• 1187828-74-5 C₁₆H₂₁NO 
• 1187828-76-7 2-(4-(tert-butyl)phenyl)-5-(4-fluorophenyl)oxazole 
• 1187828-77-8 C₁₇H₂₃NO 

Relevant articles and documents

Anodic Oxidation of Aminotetrazoles: A Mild and Safe Route to Isocyanides

A new electrochemical method for the preparation of isocyanides from easily accessible aminotetrazole derivatives has been developed, which tolerates an unprecedented range of functional groups. The use of chemical, rather than electrochemical, oxidation to afford isocyanides was also demonstrated, which provides access to these compounds for those without electrosynthesis equipment. The practicality of scale-up using flow electrochemistry has been demonstrated, in addition to the possibility of using electrochemically generated isocyanides in further reactions.

Isocyanide-based multicomponent reaction 'without' isocyanides

We present here a one-pot, four-component sequence that affords Ugi-type adducts starting from simple benzyl or allyl bromides. The isocyanides are prepared in situ under alkylation of silver cyanide salts and the resulting mixture is directly used in a U

A convenient method for the preparation of benzyl isocyanides

Treatment of benzyl halides with silver salts (AgClO4, AgBF 4, or AgOTf) and trimethylsilyl cyanide (TMSCN) in CH 2Cl2 followed by cleavage of the carbon-silicon bond with aqueous NaHCO3 or TBAF directly afforded the corresponding isocyanides. Georg Thieme Verlag Stuttgart.