728925-56-2

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 20972-37-6 (E)-4-(4-methoxyphenyl)-4-oxo-2-butenoic acid 

Downstream Products

• 728925-59-5 N-[(2E)-4-(4-methoxyphenyl)-4-oxobut-2-enoyl]-L-leucine 
• 1269627-56-6 N-[(2E)-4-(4-methoxyphenyl)-4-oxobut-2-enoyl]-L-valine 
• 82311-00-0 O-methyl-L-homotyrosine 
• 82310-97-2 (R)-2-amino-4-(4-methoxyphenyl)butanoic acid 

Relevant academic research and scientific papers

Crystallization-induced asymmetric transformation. Application to conjugate addition of benzylamine to amides of benzoylacrylic acid

Adducts of the conjugate addition of benzylamine to enantiopure amides of aroylacrylic acid possess high enantiomeric and diastereomeric purity. A high degree of stereoselectivity has been achieved by means of crystallization- induced asymmetric transform

Crystallisation-induced asymmetric transformation (CIAT) for the synthesis of dipeptides containing homophenylalanine

A novel synthesis of highly enantioenriched dipeptides containing homophenylalanine is described. The process involves a crystallisation-induced asymmetric transformation (CIAT) in a Michael addition followed by exhaustive reduction. A unique example of a formally stereodivergent CIAT in conjugate addition of an achiral N-nucleophile to enantiomerically pure Michael acceptor has been discovered.