72897-60-0Relevant academic research and scientific papers
The antileishmanial potential of C-3 functionalized isobenzofuranones against Leishmania (Leishmania) Infantum Chagasi
Pereira, Wagner Luiz,De Souza Vasconcellos, Raphael,Mariotini-Moura, Christiane,Gomes, Rodrigo Saar,De Cássia Firmino, Rafaela,Da Silva, Adalberto Manoel,Júnior, Abelardo Silva,Bressan, Gustavo Costa,Almeida, Márcia Rogéria,Afonso, Luís Carlos Crocco,Teixeira, Róbson Ricardo,Fietto, Juliana Lopes Rangel,McPhee, Derek J.
, p. 22435 - 22444 (2016/01/25)
Leishmaniases are diseases caused by protozoan parasites of the genus Leishmania. Clinically, leishmaniases range from cutaneous to visceral forms, with estimated global incidences of 1.2 and 0.4 million cases per year, respectively. The treatment of thes
An approach to dihydroisoindolobenzodiazepinones - Three-dimensional molecular frameworks
Yaremenko, Anatoliy G.,Shelyakin, Vyacheslav V.,Volochnyuk, Dmitriy M.,Rusanov, Eduard B.,Grygorenko, Oleksandr O.
, p. 1195 - 1197 (2013/03/13)
A concise two-step procedure is developed for the preparation of dihydroisoindolobenzodiazepinones, which represent derivatives of three-dimensional molecular frameworks derived from classical privileged structures of medicinal chemistry. The method commences from the readily available starting materials (i.e., 2-formylbenzoic acid, o-phenylenediamine, and various ketones) and enables the synthesis of the title compounds in 58-82% overall yields.
