72912-38-0

Basic information

• Product Name: 2-BroMo-3,4-diMethoxy-benzeneMethanol
• Synonyms: 2-BroMo-3,4-diMethoxy-benzeneMethanol;2-BroMoveratryl Alcohol;(2-BROMO-3,4-DIMETHOXYPHENYL)METHANOL
• CAS NO: 72912-38-0
• Molecular Formula: C₉H₁₁BrO₃
• Molecular Weight: 247.08584
• Product Categories: Aromatics;Intermediates
• Mol File: 72912-38-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 76-79 °C
• Boiling Point: 320.6±37.0 °C(Predicted)
• Appearance: /
• Density: 1.475±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Dichloromethane, Methanol
• PKA: 13.77±0.10(Predicted)
• CAS DataBase Reference: 2-BroMo-3,4-diMethoxy-benzeneMethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BroMo-3,4-diMethoxy-benzeneMethanol(72912-38-0)
• EPA Substance Registry System: 2-BroMo-3,4-diMethoxy-benzeneMethanol(72912-38-0)

Safety Data

• Hazardous Substances Data: 72912-38-0(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

2-BroMoveratryl Alcohol can be used in the preparation of isoquinoline and dibenzoquinolizine derivatives as antibacterial agents.

Upstream product

• 55171-60-3 2-bromo-3,4-dimethoxybenzylaldehyde 
• 2973-58-2 2-bromoisovanillin 
• 621-59-0 isovanillin 
• 2459-83-8 2-Bromo-3-hydroxy-4-methoxybenzyl Alcohol 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 7477-50-1 2-bromo-1-chloromethyl-3,4-dimethoxy-benzene 
• 72912-40-4 (2-bromo-3,4-dimethoxyphenyl)ethylamine 
• 104113-97-5 N-<2-hydroxy-2-(4-methoxyphenyl)ethyl>-2-(2-bromo-3,4-dimethoxyphenyl)ethylamine 
• 71157-96-5 6-bromo-7,8-dimethoxy-1-(p-methoxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine 
• 67287-79-0 6-bromo-7,8-dihydroxy-1-(p-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide 
• 1620095-94-4 2-bromo-3,4-dimethoxy-1-(2,2,2-trifluoroethyl)benzene 
• 1411714-30-1 C₃₂H₃₃NO₅ 
• 1411714-34-5 C₃₂H₂₉NO₄ 
• 1254068-24-0 N-(2,3-dimethoxyphenethyl)-2-[(2-(4-biphenyl)-3,4-dimethoxyphenyl)]acetamide 
• 1254068-68-2 C₃₂H₃₁NO₄ 
• 1254068-25-1 1-[2-(biphenyl-4-yl)-3,4-dimethoxybenzyl]-5,6-dimethoxyisoquinoline 
• 1254068-23-9 N-[2-[1-(2,3-dimethoxyphenyl)]-ethyl]2-bromo-3,4-dimethoxyphenylacetamide 
• 1411713-99-9 C₃₄H₃₀NO₄⁽¹⁺⁾ 
• 1411713-95-5 C₃₃H₂₈NO₄⁽¹⁺⁾ 

Relevant articles and documents

ANTIMICROBIAL AGENTS

The invention provides a compound of formula (I): or a salt or prodrug thereof, wherein Y, W, Z, Z1, Z2, Z3, Z4, and R1- R12 have any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as antibacterial agents

Synthesis of phthalideisoquinoline and protoberberine alkaloids and indolo[2,1-α]isoquinolines in a divergent route involving palladium(0)- catalyzed carbonylation

6,7,3',4'-Alkoxy-substituted 1-(2'-bromobenzoyl)-3,4-dihydroisoquinoline methiodides 17 were treated with sodium borohydride in methanol or acetic acid to give erythro-1-(2'-bromo-α-hydroxybenzyl)-2-methyl-1,2,3,4- tetrahydroisoquinolines 19. Treatment of 17 with lithium aluminum hydride in tetrahydrofuran gave the threo-isomer 20 in preference to the erythro 19. On the basis of studies on palladium(0)-catalyzed carbonylation of 2-bromo-3,4- dimethoxybenzyl alcohol to 6,7-dimethoxyphthalide, amino alcohol 19 or 20 was treated with a catalytic amount of palladium(II) acetate and triphenylphosphine in an atmosphere of carbon monoxide in the presence of chlorotrimethylsilane and potassium carbonate in boiling toluene to give the corresponding erythro- or threo-types of phthalideisoquinoline alkaloids 1 or 2, respectively. One-pot cyclization of the erythro-amino alcohols 19 was achieved by heating in N,N-dimethylformamide containing potassium carbonate to give 2,3,8,9- or 2,3,9,10-alkoxy-substituted 5,6-dihydroindolo[2,1- α]isoquinolines 3, which have a unique tetracyclic skeleton characteristic of dibenzopyrrocoline alkaloids. Similarly, palladium-(0)-catalyzed carbonylation of 1-(2'-bromobenzyl)tetrahydroisoquinolines 21 in the presence of excess potassium carbonate was found to give 8-oxoberbines 22, which on reduction with lithium aluminum hydride can be converted to protoberberine alkaloids 4.

Synthesis and renal vasodilator activity of some dopamine agonist 1-aryl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diols: Halogen and methyl analogues of fenoldopam

-