72912-99-3Relevant academic research and scientific papers
Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases
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Paragraph 0372, (2015/09/22)
The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.
MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
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, (2012/12/14)
The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS AND OTHER CHRONIC DISEASES
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, (2012/04/23)
The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.
Hydroxy cycloalkyl fused pyridone carboxylic acid M1 positive allosteric modulators
Kuduk, Scott D.,DiPardo, Robert M.,Beshore, Douglas C.,Ray, William J.,Ma, Lei,Wittmann, Marion,Seager, Matthew A.,Koeplinger, Kenneth A.,Thompson, Charles D.,Hartman, George D.,Bilodeau, Mark T.
scheme or table, p. 2538 - 2541 (2010/08/05)
Incorporation of hydroxycycloalkyl fused pyridone carboxylic acids in lieu of quinolone carboxylic acids enhance free fraction without increased susceptibility to P-glycoprotein transport.
A Synthesis of 5-Amino- and 5-Hydroxy-1-ethyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acids and Their Derivatives
Tamura, Yasumitsu,Fujita, Masanobu,Chen, Ling Ching,Ueno, Kyoji,Kita, Yasuyuki
, p. 289 - 296 (2007/10/02)
The synthesis and antimicrobial activity of 5-amino- and 5-hydroxy-1-ethyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids and their derivatives have been investigated.The 5-hydroxy-3-quinolinecarboxylic acids were prepared by thermal cyclization of 3-oxocyclohexenylaminomethylenemalonates followed by aromatization with iodine-etahnol, ethylation and hydrolysis of products.The 5-amino derivatives were prepared by several steps involving novel aromatization of isoxazole intermediates.
4-Hydroxy-5,6,7,8-tetrahydroquinoline-3-carboxylic acids and derivatives
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, (2008/06/13)
Disclosed is a quinoline derivative having the general formula STR1 where A represents a six-membered hydrocarbon ring; X represents an oxygen atom, an =NOR1 group in which R1 is a hydrogen atom or a lower alkyl radical of from 1 to
