82419-95-2Relevant articles and documents
A Synthesis of 5-Amino- and 5-Hydroxy-1-ethyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acids and Their Derivatives
Tamura, Yasumitsu,Fujita, Masanobu,Chen, Ling Ching,Ueno, Kyoji,Kita, Yasuyuki
, p. 289 - 296 (2007/10/02)
The synthesis and antimicrobial activity of 5-amino- and 5-hydroxy-1-ethyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids and their derivatives have been investigated.The 5-hydroxy-3-quinolinecarboxylic acids were prepared by thermal cyclization of 3-oxocyclohexenylaminomethylenemalonates followed by aromatization with iodine-etahnol, ethylation and hydrolysis of products.The 5-amino derivatives were prepared by several steps involving novel aromatization of isoxazole intermediates.
