72917-35-2Relevant academic research and scientific papers
New trimethoxybenzamides and trimethoxyphenylureas derived from dimethylcarbazole as cytotoxic agents. Part i
Panno, Antonella,Sinicropi, Maria Stefania,Caruso, Anna,El-Kashef, Hussein,Lancelot, Jean-Charles,Aubert, Geneviève,Lesnard, Aurélien,Cresteil, Thierry,Rault, Sylvain
, p. E294-E302 (2014/11/08)
A convenient synthesis of novel functionalized 1,4-dimethylcarbazole derivatives containing 3,4,5-trimethoxybenzamido-ureido or N-(3,4,5- trimethoxyphenyl)ureido group starting from their corresponding indole derivatives is reported. Three derivatives pre
Etude de la cytotoxicite in vitro de derives du carbazole III. 3-Amino et 3-nitro-1,4-dimethyl-9H-carbazoles diversement substitutes en position 6
Letois, B,Lancelot, J C,Rault, S,Robba, M,Tabka, T,et al.
, p. 775 - 784 (2007/10/02)
The synthesis of a series of nitro and amino-1,4-dimethyl-9H-carbazoles is described.The cytotoxic activities, as assayed in vitro using clonogenic cell culture of murine leukemia L1210, vary greatly with the nature and position of substituents.The most cytotoxic derivatives, 3-amino-6-hydroxy 1,4-dimethyl-9H-carbazole, displays an activity similar to that of N2-methyl-9-hydroxy ellipticinium acetate (NMHE).These results, together with those previously published by us, allow a detailed analysis of structure-activity relationships in the 9H-carbazole and1,4-dimethyl-9H-carbazole series.For the 3-amino-1,4-dimethyl 9H-carbazole derivatives, a mechanism of action similar to that of ellipticine derivatives is proposed.
A SIMPLE ROUTE TO 3-AMINO-1,4-DIMETHYL-6-HYDROXY- (OR METHOXY-)CARBAZOLES
Lancelot, Jean-Charles,Letois, Bertrand,Rault, Sylvain,Robba, Max
, p. 241 - 246 (2007/10/02)
A convenient synthesis of 3-amino-1,4-dimethyl-6-hydroxy- (or methoxy-)carbazoles was described starting from 1,4-dimethyl-6-hydroxycarbazole.Structures were confirmed by unequivocal synthesis.
Condensation of p-Benzoquinone with 4-Cyano- and 4-Nitroanilines. An Extension of the Nenitzescu Reaction
Bernier, Jean-Luc,Henichart, Jean-Pierre,Vaccher, Claude,Houssin, Raymond
, p. 1493 - 1496 (2007/10/02)
A new synthesis of the 6-hydroxycarbazole ring involving the condensation of p-benzoquinone with various electron-withdrawing activated anilines has been presented.This procedure, an extension of the Nenitzescu reaction, gave multiple products identified on the basis of physical and spectral data.The corresponding mechanisms are described.
