7292-39-9

Upstream product

• 114790-35-1 dibenzyl hydroxymethylphosphonate 
• 100-51-6 benzyl alcohol 
• 253682-73-4 dibenzyl (bromomethyl)phosphonate 
• 17176-77-1 Dibenzyl phosphite 
• 133918-47-5 tetrabenzyl methylenediphosphonate 
• 166049-85-0 methylenebisphosphonic acid tribenzyl methyl ester 

Downstream Products

• 253682-74-5 {Benzyloxy-[(3aR,4R,6R,6aR)-6-(4-carbamoyl-thiazol-2-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy]-phosphorylmethyl}-phosphonic acid dibenzyl ester 
• 253682-75-6 {Benzyloxy-[(3aR,4R,6R,6aR)-6-(4-carbamoyl-thiazol-2-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy]-phosphorylmethyl}-phosphonic acid monobenzyl ester 
• 229344-02-9 3'-azido-3'-deoxy-5'-O-[(bis-benzyloxyphosphorylmethyl)benzyloxyphosphoryl]-N³-{1-[5-(2,2,2-trifluoroacetylamino)pentyl]}-α-thymidine 
• 229343-97-9 3'-azido-3'-deoxy-5'-O-[(bis-benzyloxyphosphorylmethyl)benzyloxyphosphoryl]-N³-{1-[5-(2,2,2-trifluoro-acetylamino)pentyl]}thymidine 

Relevant academic research and scientific papers

Synthesis and evaluation of stable substrate analogs as potential modulators of cyclodiphosphate synthase IspF

Stable IspF substrate analogs were synthesized. In the presence of substrate analogs, the E. coli IspF-MEP complex shows activities distinct from IspF, and bisphosphonates (BP) behave differently than their diphosphate (DP) counterparts. Bisphosphonate an

COMPOSITIONS AND METHODS OF MODULATING THE IMMUNE RESPONSE BY ACTIVATING ALPHA PROTEIN KINASE 1

The disclosure provides compositions and methods related to activating alpha-kinase 1 (ALPK1) for modulating an immune response and treating or preventing cancer, infection, inflammation and related diseases and disorders as well as potentiating an immune response to a target antigen. The disclosure also provides heterocyclic compounds of formula (I) as agonists of alpha protein kinase 1 (ALPK1) and their use in activating ALPK1, modulating an immune response and treating diseases such as cancer, wherein A1, A2, L1, L2, L3, Z1, Z2, W1, W2, R1, R2, R3, R4, R5, R6 and R7 are defined herein.

The assembly of β-methylene-TAD, a metabolically stable analogue of the antitumor agent TAD, by the stepwise esterification of monodeprotected methylenebis-(phosphonate) benzyl esters under Mitsunobu conditions

Synthesis of the metabolically stable analogue of thiazole-4-carboxamide adenine dinucleotide (β-methylene-TAD) was achieved via the sequential monodeprotection of tetrabenzyl methylenebis(phosphonate) after two rounds of Mitsunobu esterifications with th

First Use of Benzyl Phosphites in the Michaelis-Arbuzov Reaction Synthesis of Mono-, Di-, and Triphosphate Analogs

Benzyl phosphites were used in the Michaelis-Arbuzov reaction.Special experimental conditions allowed preparation of a set of phosphonate analogs of mono-, di-, and triphosphate.Furthermore, regioselective mono-deprotection mades these molecules useful building blocks for the synthesis of analogs of polyphosphorylated compounds of biological interest (e.g. nucleotides), after removal of all phosphonate benzyl ester groups under very mild conditions and high yields.