7295-02-5Relevant academic research and scientific papers
Pyrimidine 2,4-Diones in the design of new HIV RT inhibitors
Romeo, Roberto,Iannazzo, Daniela,Veltri, Lucia,Gabriele, Bartolo,Macchi, Beatrice,Frezza, Caterina,Marino-Merlo, Francesca,Giofrè, Salvatore V.
, (2019/05/27)
The pyrimidine nucleus is a versatile core in the development of antiretroviral agents. Onthis basis, a series of pyrimidine-2,4-diones linked to an isoxazolidine nucleus have been synthesized and tested as nucleoside analogs, endowed with potential anti-
Sulfonamide derivatives
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Page column 145, (2010/02/05)
A compound of the formula (I) or a pharmacologically acceptable salt, ester or other derivative thereof: R1is H or NHOH. R2is H, optionally substituted alkyl, cycloalkyl or a group —AR6. A is an alkylene which may be optionally interrupted by O, —S(O)m— or —N(R9). R6is a group (II), (III), (IV) X is O, S, —N(R10)—, —C(R11)(R12)—. Y is O, CO, —S(O)n—, —N(R10)—, —C(R11)(R12)—. Each of R7and R8is H, alkyl, COOH, optionally substituted alkyl, etc. Each of R9, R10, R11, and R12is H, alkyl, etc. Each of m and n is 0 to 2. R3is H, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl. R4is optionally substituted (hetero)arylene. R5is optionally substituted alkyl, optionally substituted (hetero)aryl. These compounds have matrixmetalloproteinase—13 inhibitory activity and aglycanase inhibitory activity.
