7295-18-3

Upstream product

• 106-47-8 4-chloro-aniline 
• 93-91-4 1-phenylbutan-1,3-dione 

Relevant academic research and scientific papers

Synthesis, characterization and crystal structure of (Z)-3-(4- chlorophenylamino)-1-Phenylbut-2-En-1-One

The title compound (Z)-3-(4-chlorophenylamino)- 1-phenylbut-2-en-1-one, has been prepared in good yield from the condensation reaction of benzoylacetone and 4-chloroaniline, catalyzed by two drops of formic acid. The compound was characterized by 1H NMR, 13C NMR, IR spectroscopy, mass spectrometry, elemental analysis, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), and single crystal X-ray diffraction. The compound crystallized in the monoclinic crystal system with space group P21/n, Z = 4, V = 1370.3(7) A3, and unit cell parameters a = 6.4063(19) A, b = 7.085(2) A, c = 30.194(9) A, α = 90°, β = 90.824(5)° and γ = 90°. The crystal structure reveals that the compound exists in the enamino-ketone form and not the enol-imine form. Moreover, TGA/DSC analyses of the title compound was studied, showing two distinct endothermic peaks at temperatures of 134.05 and 302.71 °C, corresponding to melting and boiling points, respectively. Springer Science+Business Media, LLC 2012.

A Reusable CNT-Supported Single-Atom Iron Catalyst for the Highly Efficient Synthesis of C?N Bonds

C?N bond formation is regarded as a very useful and fundamental reaction for the synthesis of nitrogen-containing molecules in both organic and pharmaceutical chemistry. Noble-metal and homogeneous catalysts have frequently been used for C?N bond formatio

Solvent-free synthesis of β-enamino ketones and esters catalysed by recyclable iron(III) triflate

A novel application of highly stable Fe(OTf)3 as an efficient catalyst for the synthesis of a variety of β-enamino ketones and esters under solvent-free conditions is described. Notably, this protocol of a "green synthesis", which produced β-enamino ketones and esters by the reaction of a variety of β-dicarbonyl compounds and primary amines, exhibits attractive properties including high yields, short reaction periods, lower loading of catalyst and chemo- and regio-selectivity. In addition, the catalyst was easily recovered from the reaction system and readily reused with minimal loss of activity.

A facile route to lithium complexes supported by β-ketoiminate ligands and their reactivity

Several β-ketoiminate lithium complexes Li2(L) 2·2(THF) (6-10) were conveniently synthesized by using 1 equiv. of n-BuLi with 1 equiv. of β-ketoiminate ligands (1-5) in THF-hexane at 60 C. All the new complexes have been characterize

Zinc triflate catalysed synthesis of β-enamino ketones(esters) under solvent-free conditions

An efficient and mild procedure is described for the synthesis of a series of β-enamino ketones(esters) from 1,3-dicarbonyl compounds and aliphatic and aromatic amines using zinc triflate as the catalyst.

Formic acid: A low-cost, mild, ecofriendly, and highly efficient catalyst for the rapid synthesis of β-enaminones

β-Enaminones have been synthesized by the condensation reaction of b-diketones with various anilines in the presence of a catalytic amount of formic acid, mild and highly efficient acid catalyst in methanol. These condensation reactions proceed smoothly in short reaction times with near-quantitative yields. Copyright

Silica supported Fe(HSO4)3 as an efficient, heterogeneous and recyclable catalyst for synthesis of β-enaminones and β-enamino esters

A series of β-substituted enaminones were prepared through the one-pot reaction of β-dicarbonyl compounds with various amines in the presence of silica ferric hydrogensulfate under solvent free conditions at room temperature. The reactions proceed smoothl

Solid-state synthesis of β-enamino ketones from solid 1,3-dicarbonyl compounds and ammonium salts or amines

A facile amination of solid 1,3-dicarbonyl compounds with ammonium salts or amines in solid state has been achieved by mechanochemical grinding in the presence of KHSO4 and SiO2. Most of the reactions proceed smoothly at room temperature under solid-state conditions and give their corresponding β-imino derivatives in high yields. The method has the advantage of simple manipulation and mild conditions. Georg Thieme Verlag Stuttgart.