72955-72-7Relevant academic research and scientific papers
3-Silaazetidine: An Unexplored yet Versatile Organosilane Species for Ring Expansion toward Silaazacycles
Dong, Xue,Gao, Lu,He, Yuanhang,Li, Linjie,Song, Zhenlei,Wang, Qiantao,Wang, Wanshu,Zhou, Song
, p. 11141 - 11151 (2021)
Small-ring silacycles are important organosilane species in main-group chemistry and have found numerous applications in organic synthesis. 3-Silaazetidine, a unique small silacycle bearing silicon and nitrogen atoms, has not been adequately explored due to the lack of a general synthetic scheme and its sensitivity to air. Here, we describe that 3-silaazetidine can be easily prepared in situ from diverse air-stable precursors (RSO2NHCH2SiR12CH2Cl). 3-Silaazetidine shows excellent functional group tolerance in a palladium-catalyzed ring expansion reaction with terminal alkynes, giving 3-silatetrahydropyridines and diverse silaazacycle derivatives, which are promising ring frameworks for the discovery of Si-containing functional molecules.
A Novel Cleavage Technique to Generate Small Molecule Compounds and Libraries via a Two-Resin System
Ouyang, Xiaohu,Armstrong, Robert W.,Murphy, Martin M.
, p. 1027 - 1032 (2007/10/03)
Application of organic synthesis to solid supports has led to the successful implementation of combinatorial chemistry in the drug discovery process. This paper describes a novel use of the Hofmann elimination of tetrasubstituted amine salts on solid-phas
Certain ovicidal piperazines
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, (2008/06/13)
It has been found that compounds of the structure STR1 wherein "pyr" stands for 2-, 3-, or 4-pyridyl; Z is CO or (CH2)n ; n is 0, 1 or 2; R is hydrogen, halogen, loweralkyl, loweralkyloxy, nitro, or hydroxymethyl; and R' is hydrogen
