729554-57-8Relevant academic research and scientific papers
Beta-amino acid derivatives as orally active non-peptide fibrinogen receptor antagonists
Kottirsch, Georg,Zerwes, Hans-Guenther,Cook, Nigel S.,Tapparelli, Carlo
, p. 727 - 732 (2007/10/03)
The ornithine sulfonamide 1 was identified by random screening as weak fibrinogen receptor antagonist. Homologation of the carboxylic acid function and further structure activity studies led to the development of novel beta-amino acid derivatives, which are potent and orally active antagonists of the platelet fibrinogen receptor GPIIb/IIIa.
