729599-79-5

Upstream product

• 103239-04-9 N-(p-anisyl)-4-<(S)-2',2'-dimethyl-1',3'-dioxolan-4'-yl>-methylene-imine 
• 141781-24-0 [1-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-meth-(E)-ylidene]-(4-methoxy-phenyl)-amine 
• 61350-60-5 (S)-benzyloxycarbonyl-proline acid chloride 
• 729599-78-4 (-)-(3R,4R)-5-benzyloxycarbonyl-2-(4-methoxyphenyl)-3-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,5-diazaspiro[3.4]octan-1-one 

Downstream Products

• 787617-96-3 (-)-(3R,4R)-5-benzyloxycarbonyl-2-(tert-butoxycarbonyl)-3-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,5-diazaspiro[3.4]octan-1-one 
• 729599-83-1 (1R,4R)-1-Formyl-3-oxo-2,5-diaza-spiro[3.4]octane-5-carboxylic acid benzyl ester 
• 729599-81-9 (1R,4R)-1-((S)-1,2-Dihydroxy-ethyl)-3-oxo-2,5-diaza-spiro[3.4]octane-5-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Diastereoselective [2+2]-cycloaddition reactions of unsymmetrical cyclic ketenes with imines: Synthesis of modified prolines and theoretical study of the reaction mechanism

The synthesis of enantiomerically pure modified proline derivatives was achieved by using spiro β-lactams as starting material that were prepared in turn by the [2+2]-cycloaddition of unsymmetrical cyclic ketenes with optically active imines. A theoretica

Unusual rearrangement of spiro β-lactams to 1,4-diazabicyclo[4,4,0] decanes and 1,4-diazabicyclo[4,3,0]nonanes. Synthesis of conformationally restricted σ-receptor ligands

Synthesis of 1,4-diazabicyclo[4,4,0]decanes and 1,4-diazabicyclo[4,3,0] nonanes was achieved by using 4-formyl spiro β-lactams as easily available starting materials. Furthermore, the application of this protocol to the preparation of conformationally res