72961-56-9Relevant academic research and scientific papers
Regioselective preparation of 2-phenylethylamines from 1-phenyl-2-alkyl- alkynes by hydroamination/reduction sequences
Heutling, Andreas,Severin, Rene,Doye, Sven
, p. 1200 - 1204 (2005)
Ind2TiMe2 is a highly active and general catalyst for the intermolecular hydroamination of alkynes. Particularly impressive is that Ind2TiMe2 makes it possible to perform hydroamination reactions of unsymmetrically substituted 1-phenyl-2-alkylalkynes with primary aryl-, tert-alkyl-, sec-alkyl-, and n-alkylamines in a highly regioselective fashion. Since the initially formed imines can easily be reduced with zinc-modified NaBH3CN, 2-phenylethylamines are accessible in reliable one-pot procedures from 1-phenyl-2-alkylalkynes and primary amines on a 10 mmol scale.
