729610-45-1Relevant academic research and scientific papers
An efficient synthesis of novel 1,3-oxazolo[4,5-d]pyridazinones
Frolov, Eugene B.,Lakner, Frederick J.,Khvat, Alexandre V.,Ivachtchenko, Alexandre V.
, p. 4693 - 4696 (2004)
A convenient and versatile synthetic approach to substituted 1,3-oxazolo[4,5-d]pyridazinones is developed. The oxazole ring was formed upon reaction of 5-amino-4-hydroxy-3(2H)-pyridazinone with various carboxylic acid derivatives using a microwave-assisted procedure, which favors the reaction time and purity of the resulting products. The developed methodology is suitable for rapid, parallel, automated synthesis of oxazolopyridazinone libraries.
