72972-77-1

Upstream product

• 72972-75-9 4-Benzoyl-3-isopropyl-6-methyl-1-phenyl-5-hepten-1-one 
• 98-86-2 acetophenone 

Downstream Products

• 72972-87-3 3-(3,3-dimethyl-oxiranyl)-4-isopropyl-2,6-diphenyl-pyridine 
• 85474-84-6 8-Isopropyl-10,10-dimethyl-6-phenyl-9,10-dihydro-5-azaphenanthren-9-one 

Relevant academic research and scientific papers

A green synthesis of highly substituted 1,5-diketones

Highly substituted 1,5-diketones have been synthesized in water via the reactions between aryl methyl ketones and aldehydes and the subsequent dimerizations. The reaction was catalyzed by aqueous KOH. The advantages of these aqueous reactions over organic-solvent mediated reactions are better yields, better diastereoselectivities, faster reaction rates, simpler workups, and being more energy efficient. The reaction can be scaled up to 13.9 gram scale and the aqueous KOH can be reused for five cycles. A possible mechanism is proposed to explain the high diastereoselectivities.

CONDENSATION OF ALDEHYDES AND KETONES. XXIII. ALKALINE CONDENSATION OF ACETOPHENONE WITH ISOBUTYRALDEHYDE

The reaction of acetophenone with isobutyraldehyde in aqueous alcohol solutions of alkali leads to 4-benzoyl-3-isopropyl-6-methyl-1-phenyl-5-hepten-1-one.The reaction take place differently in an alkaline water-DMSO solution. (3-Isopropyl-1,5-diphenyl-1,5