72973-85-4Relevant academic research and scientific papers
Synthesis of Pseudo Cofactor Analogues as Potential Inhibitors of the Folate Enzymes
Temple, Carroll,Bennett, L. Lee,Rose, Jerry D.,Elliott, Robert D.,Montgomery, John A.,Mangum, John H.
, p. 161 - 166 (2007/10/02)
Reaction of 5,6,7,8-tetrahydrofolic acid (THF, 7) with phosgene, thiophosgene, and cyanogen bromide gave the bridged derivatives, 5,10-(CO)-THF (8), 5,10-(CS)-THF (9), and 5,10-(C=NH)-THF (11), respectively.Catalytic hydrogenation of 10-(chloroacetyl)foli
