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(TRIMETHYLSILYL)ACETYLENE-D, also known as TMS acetylene-d, is a chemical compound with the formula C5H6Si. It is a deuterated derivative of trimethylsilylacetylene, which is commonly used in organic synthesis and in the production of silicon-containing materials. TMS acetylene-d is a stable, colorless liquid that is highly flammable and may react violently with oxidizing agents.

7299-46-9

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7299-46-9 Usage

Uses

Used in Organic Synthesis:
(TRIMETHYLSILYL)ACETYLENE-D is used as a reagent for the synthesis of deuterated compounds in organic chemistry. Its application is particularly valuable for enhancing the understanding of molecular structures and properties through nuclear magnetic resonance (NMR) spectroscopy.
Used in Silicon-Containing Material Production:
(TRIMETHYLSILYL)ACETYLENE-D is used as a precursor in the production of silicon-containing materials, which have a wide range of applications in various industries, including electronics, construction, and automotive.
Used in Research and Development:
(TRIMETHYLSILYL)ACETYLENE-D is used as a research compound for the development of new chemical processes and materials, given its unique properties and reactivity.
Used in Pharmaceutical Industry:
(TRIMETHYLSILYL)ACETYLENE-D is used as a starting material for the synthesis of deuterated pharmaceutical compounds, which can have improved stability and reduced side effects compared to their non-deuterated counterparts.
Safety Precautions:
It is important to handle (TRIMETHYLSILYL)ACETYLENE-D with caution due to its hazardous nature and flammability. Proper safety measures, including the use of protective equipment and adherence to safety protocols, should be taken to minimize risks during its use.

Check Digit Verification of cas no

The CAS Registry Mumber 7299-46-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,2,9 and 9 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 7299-46:
(6*7)+(5*2)+(4*9)+(3*9)+(2*4)+(1*6)=129
129 % 10 = 9
So 7299-46-9 is a valid CAS Registry Number.

7299-46-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-deuterioethynyl(trimethyl)silane

1.2 Other means of identification

Product number -
Other names (Deuteroethinyl)trimethylsilan

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:7299-46-9 SDS

7299-46-9Relevant academic research and scientific papers

Microwave Spectra of Trimethylsilylethyne, Me3SiCCH, 1-Cyano-2-trimethylsilylethyne, Me3SiCCCN, and 1-Cyano-4-trimethylsilylbutadiyne, Me3Si(CC)2CN

Alexander, Anthony J.,Firth, Steven,Kroto, Harold W.,Walton, David R. M.

, p. 531 - 534 (1992)

The microwave spectra of the title compounds, recorded in the 26.5-40.0 GHz region, are characteristic of symmetric top molecules, complicated by internal rotation and accompanied by vibrational satellites attributed to low-frequency skeletal bending modes.For Me3SiCCH, B0 = 1962.163 MHz and relative intensity measurements on the vibrational satellites give a value of 110 +/- 15 cm-1 for the degenerate Si-CC bending mode.Measurements on Me3SiCCD have been made, and the Si-C bond length has been determined as 1.83 +/- 0.01 Angstroem.For Me3SiCCCN, B0 = 711.8646MHz, whilst for Me3Si(CC)2CN, twenty broad-band symmetric-top transitions, from J = 41 to 60, have been observed and a B value of 331 +/- 2 MHz has been estimated.

Reactions of five-membered zirconacycloalkynes and zirconacycloallenes with Cp2Zr(H)Cl; Formal hydrogenation by metal hydrides

Ban, Sayaka,Ito, Saki,Mochizuki, Ayari,Suzuki, Noriyuki

supporting information, p. 16265 - 16272 (2021/11/30)

Reactions of five-membered zirconacycloalkynes and zirconacyloallenes (1-zirconacyclopent-3-ynes and 1-zirconacyclopenta-2,3-dienes) with an excess of Cp2Zr(H)Cl, known as the Schwartz reagent, were studied. Both reactions gave five-membered zirconacycloalkenes, 1-zirconacyclopent-3-enes without subsequent work-up such as protonolysis and hydrogenolysis. The product was identical to the zirconocene-diene complex that was prepared from Cp2Zr(n-Bu)2 (Negishi reagent) and the corresponding 1,4-disubstituted 1,3-dienes. These results indicate that formal hydrogenation by metal hydride took place. The use of diisobutylaluminum hydride or 9-borabicyclo[3.3.1]nonane also gave the same product, albeit in lower yields. The reactions starting from deuterated compounds suggested that double hydrozirconation followed by elimination of a dinuclear zirconium complex resulted in the hydrogenated products.

Selective Oligomerization and [2 + 2 + 2] Cycloaddition of Terminal Alkynes from Simple Actinide Precatalysts

Batrice, Rami J.,McKinven, Jamie,Arnold, Polly L.,Eisen, Moris S.

, p. 4039 - 4050 (2015/09/01)

A catalyzed conversion of terminal alkynes into dimers, trimers, and trisubstituted benzenes has been developed using the actinide amides U[N(SiMe3)2]3 (1) and [(Me3Si)2N]2An[κ2-(N,C)-CH2Si(CH3)N(SiMe3)] (An = U (2), Th (3)) as precatalysts. These complexes allow for preferential product formation according to the identity of the metal and the catalyst loading. While these complexes are known as valuable precursors for the preparation of various actinide complexes, this is the first demonstration of their use as catalysts for C-C bond forming reactions. At high uranium catalyst loading, the cycloaddition of the terminal alkyne is generally preferred, whereas at low loadings, linear oligomerization to form enynes is favored. The thorium metallacycle produces only organic enynes, suggesting the importance of the ability of uranium to form stabilizing interactions with arenes and related π-electron-containing intermediates. Kinetic, spectroscopic, and mechanistic data that inform the nature of the activation and catalytic cycle of these reactions are presented. (Chemical Equation Presented).

Reactivity of individual organolithium aggregates: A RINMR study of n-butyllithium and 2-methoxy-6-(methoxymethyl)phenyllithium

Jones, Amanda C.,Sanders, Aaron W.,Bevan, Martin J.,Reich, Hans J.

, p. 3492 - 3493 (2008/01/01)

Low-temperature rapid injection NMR (RINMR) experiments were performed on two lithium reagents, n-butyllithium and 2-methoxy-6-(methoxymethyl)phenyllithium (5), with the goal of measuring the relative reactivity of the different aggregates (dimer, mixed dimer, and tetramer for n-BuLi, monomer and tetramer for 5) toward typical electrophiles. The reaction of the n-BuLi dimer with (trimethylsilyl)acetylene first forms the mixed dimer n-BuLi·Me3SiC≡CLi, which is about 1/60 as reactive as the n-BuLi homodimer. The tetramer does not react. In the deprotonation of (phenylthio)acetylene, the n-BuLi dimer was found to be 3.5 × 108 as reactive as the tetramer, and in the addition to p-diethylaminobenzaldehyde, the relative reactivity was at least 2 × 104. In the deprotonation of (p-tolylsulfonyl)acetylene, the monomer of 5 was at least 1014 times as reactive as the tetramer. These measurements show that the difference in reactivity between the lower and higher aggregates of organolithium reagents can be many orders of magnitude higher than all previous estimates. Copyright

The mechanism of [2 + 1] and [2 + 2] cycloaddition reactions of 1-phenylseleno-2-(trimethylsilyl)ethene: An isotopic labelling study

Yamazaki, Shoko,Yanase, Yuichiro,Yamamoto, Kagetoshi

, p. 1991 - 1996 (2007/10/03)

The reactions of deuterio-labelled 1-seleno-2-sitylethenes with trimethyl 2-phosphonoacrylate 2 and methyl vinyl ketone 4 in the presence of SnCl4 gave deuterio-substituted cyclopropanes with 1,2-silicon migration. The reaction of deuterio-labe

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