730-63-2

Basic information

• Product Name: 2,2,2-trifluoro-1-(2-chlorophenyl)-1-phenylethanol
• Synonyms: 2,2,2-trifluoro-1-(2-chlorophenyl)-1-phenylethanol
• CAS NO: 730-63-2
• Molecular Weight: 286.681
• Mol File: 730-63-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2,2,2-trifluoro-1-(2-chlorophenyl)-1-phenylethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-trifluoro-1-(2-chlorophenyl)-1-phenylethanol(730-63-2)
• EPA Substance Registry System: 2,2,2-trifluoro-1-(2-chlorophenyl)-1-phenylethanol(730-63-2)

Safety Data

• Hazardous Substances Data: 730-63-2(Hazardous Substances Data)

Upstream product

• 694-80-4 2-bromo-1-chlorobenzene 
• 434-45-7 2,2,2-Trifluoroacetophenone 
• 75-46-7 trifluoromethan 
• 5162-03-8 (2-chlorophenyl)(phenyl)methanone 

Relevant articles and documents

Gas/Liquid-Phase Micro-Flow Trifluoromethylation using Fluoroform: Trifluoromethylation of Aldehydes, Ketones, Chalcones, and N-Sulfinylimines

A micro-flow nucleophilic trifluoromethylation of carbonyl compounds using gaseous fluoroform was developed. This method also allows the first micro-flow transformation of N-sulfinylimines into trifluoromethyl amines with excellent diastereoselectivity. To demonstrate the synthetic utility of this micro-flow synthesis, the formal micro-flow synthesis of Efavirenz is described.

Organocatalyzed Trifluoromethylation of Ketones and Sulfonyl Fluorides by Fluoroform under a Superbase System

Fluoroform (HCF3, HFC-23) is a side product in the manufacture of polytetrafluoroethylene (Teflon). Despite its attractive properties, taming HCF3 for trifluoromethylation is quite problematic owing to its low acidity and the labilit