730-64-3Relevant academic research and scientific papers
Gas/Liquid-Phase Micro-Flow Trifluoromethylation using Fluoroform: Trifluoromethylation of Aldehydes, Ketones, Chalcones, and N-Sulfinylimines
Hirano, Kazuki,Gondo, Satoshi,Punna, Nagender,Tokunaga, Etsuko,Shibata, Norio
, p. 406 - 410 (2019/02/13)
A micro-flow nucleophilic trifluoromethylation of carbonyl compounds using gaseous fluoroform was developed. This method also allows the first micro-flow transformation of N-sulfinylimines into trifluoromethyl amines with excellent diastereoselectivity. To demonstrate the synthetic utility of this micro-flow synthesis, the formal micro-flow synthesis of Efavirenz is described.
Anion-Initiated Trifluoromethylation by TMSCF3: Deconvolution of the Siliconate-Carbanion Dichotomy by Stopped-Flow NMR/IR
Johnston, Craig P.,West, Thomas H.,Dooley, Ruth E.,Reid, Marc,Jones, Ariana B.,King, Edward J.,Leach, Andrew G.,Lloyd-Jones, Guy C.
supporting information, p. 11112 - 11124 (2018/09/06)
The mechanism of CF3 transfer from R3SiCF3 (R = Me, Et, iPr) to ketones and aldehydes, initiated by M+X- (0.004 to 10 mol %), has been investigated by analysis of kinetics (variable-ratio stopped-flo
Efficient synthesis of [18F]trifluoromethane and its application in the synthesis of PET tracers
Van Der Born, Dion,Herscheid,Orru, Romano V.A.,Vugts, Danielle J.
supporting information, p. 4018 - 4020 (2013/07/26)
A new strategy towards [18F]trifluoromethyl-containing compounds is developed. [18F]trifluoromethane is synthesised in a fast and efficient manner and subsequently used in the reaction with aldehydes and ketones forming [18/sup
Taming of fluoroform: Direct nucleophilic trifluoromethylation of Si, B, S, and C centers
Surya Prakash,Jog, Parag V.,Batamack, Patrice T. D.,Olah, George A.
, p. 1324 - 1327 (2013/02/22)
Fluoroform (CF3H), a large-volume by-product of the manufacture of Teflon, refrigerants, polyvinylidene fluoride (PVDF), fire-extinguishing agents, and foams, is a potent and stable greenhouse gas that has found little practical use despite the growing importance of trifluoromethyl (CF3) functionality in more structurally elaborate pharmaceuticals, agrochemicals, and materials. Direct nucleophilic trifluoromethylation using CF3H has been a challenge. Here, we report on a direct trifluoromethylation protocol using close to stoichiometric amounts of CF3H in common organic solvents such as tetrahydrofuran (THF), diethyl ether, and toluene. The methodology is widely applicable to a variety of silicon, boron, and sulfur-based electrophiles, as well as carbon-based electrophiles.
