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Usage

Uses

Used in Chemical Synthesis:
5-Chlorobiphenyl-2-amine is used as a key intermediate in the synthesis of other organic compounds, leveraging its unique structural features to facilitate the creation of a range of chemical products.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 5-chlorobiphenyl-2-amine is utilized as a building block in the production of various drugs. Its presence in the molecular structure of these drugs can influence their pharmacological properties and therapeutic effects.
Used in Research and Development:
5-Chlorobiphenyl-2-amine is also employed in research and development processes within the chemical industry. It serves as a valuable tool for scientists to explore new chemical reactions and pathways, potentially leading to the discovery of innovative materials and pharmaceuticals.
Each application underscores the compound's significance in the broader context of chemical and pharmaceutical innovation, highlighting its multifaceted role in the synthesis of new compounds and the advancement of existing products.

Upstream product

• 823-86-9 N-(4-chlorophenyl)hydroxylamine 
• 71-43-2 benzene 
• 107940-74-9 N-(N-4-chlorophenylamino)phthalimide 
• 7647-01-0 hydrogenchloride 
• 64-17-5 ethanol 
• 86-00-0 2-nitrobiphenyl 

Downstream Products

• 7148-08-5 N-(5-chloro-[1,1'-biphenyl]-2-yl)acetamide 
• 76838-45-4 1-Benzoyl-3-(5-chloro-biphenyl-2-yl)-thiourea 
• 27353-44-2 2-chlorophenanthridin-6(5H)-one 
• 1426813-08-2 2-chloro-5-tosylphenanthridin-6(5H)-one 
• 872809-63-7 2-chloro-6-phenylphenanthridine 
• 2051-61-8 m-chlorobiphenyl 
• 10336-16-0 3-chloro-N-acetylcarbazole 
• 94546-54-0 3-chloro-9-phenylphenanthrene 

Relevant academic research and scientific papers

Reaction of n-aminophthalimide derivatives with aluminum chloride in benzene

The reaction of N-aminophthalimide derivatives with AlCl3 in benzene has been investigated. From N-amino- and N-benzamidophthalimide (1a and 1b), N-amino- and N-benzamido3,3-diaryl-2,3-dihydroisoindol-1-ones (2) are obtained in high yield by initial attack of benzene on the imide carbonyl, assisted by the neighboring nitrogen atom. From N-arylaminophthalimide derivatives (4), the N-N bond is cleaved heterolytically to give an arylnitrenium ion and canonical forms involving the arene which are trapped by benzene to give aminobiaryls and N-arylanilines.

Acid-Catalyzed Reactions of N-Arylhydroxylamines and Related Compounds with Benzene. Iminium-Benzenium Ions

N-Arylhydroxylamines react with benzene in the presence of trifluoroacetic acid (TFA) at room temperature to give diphenylamines.When TFA was replaced by a strong acid, trifluoromethanesulfonic acid (TFSA), the major products were aminobiphenyls.The nature of the reaction was explored by reactions of 4-substituted phenylhydroxylamines and dialkylaniline N-oxides with benzene.Thus, it was demonstrated that the reactive intermediates are onium-benzenium dications which are trapped by benzene to give aminobiphenyls by a mechanism similar to the Friedel-Krafts alkylation.Further evidence for the proposed reaction mechanism was the observation that nitrosobenzene and azoxybenzene reacted with benzene to give analogous products in the presence of the stronger acid.