73007-66-6Relevant academic research and scientific papers
Copper-catalyzed aerobic oxidative inert C-C and C-N bond cleavage: A new strategy for the synthesis of tertiary amides
Chen, Xiuling,Chen, Tieqiao,Li, Qiang,Zhou, Yongbo,Han, Li-Biao,Yin, Shuang-Feng
, p. 12234 - 12238 (2014)
A copper-catalyzed aerobic oxidative amidation reaction of inert C-C bonds with tertiary amines has been developed for the synthesis of tertiary amides, which are significant units in many natural products, pharmaceuticals, and fine chemicals. This method combines C-C bond activation, C-N bond cleavage, and C-H bond oxygenation in a one-pot protocol, using molecular oxygen as the sole oxidant without any additional ligands.
