73029-28-4Relevant academic research and scientific papers
Synthesis of pyrimidine fused quinolines by ligand-free copper-catalyzed domino reactions
Panday, Anoop Kumar,Mishra, Richa,Jana, Asim,Parvin, Tasneem,Choudhury, Lokman H.
, p. 3624 - 3632 (2018/04/14)
Herein, we report two novel methods for the synthesis of pyrimidine fused quinolines using a one-pot C-C and C-N bond forming strategy from the reaction of 6-aminouracils with 2-bromobenzaldehydes or 2-bromobenzyl bromide derivatives in the presence of 10 mol % CuCl2 without using any ligand. The reaction of 2-bromobenzaldehyde or its derivatives with 6-aminouracils in the presence of K2CO3 as base and a catalytic amount of CuCl2 in DMF medium under microwave heating conditions provides corresponding pyrimidine fused quinoline derivatives in good yields within 30 min. Alternatively, pyrimidine fused quinoline derivatives have been synthesized from the reaction of 2-bromobenzyl bromides with 6-aminouracil derivatives in the presence of molecular oxygen, CuCl2 (10 mol %), and K2CO3 as base in DMF under reflux conditions. Structures of all the products were unambiguously confirmed by spectroscopic techniques and by recording single crystal XRD of 3a.
Spectroscopy and photophysics of trimethyl-substituted derivatives of 5-deazaalloxazine. Experimental and theoretical approaches
Pruka?a, Dorota,Gierszewski, Mateusz,Kubicki, Maciej,P?dziński, Tomasz,Sikorska, Ewa,Sikorski, Marek
, p. 139 - 146 (2015/02/19)
Photophysical and structural properties of 5-deazaalloxazine derivatives were studied, with methyl substituent at the position 8 or 9 of the benzene ring and at the N(1) and N(3) positions. Crystal structures of the compounds were determined by X-ray diff
