73040-60-5

Usage

Uses

Used in Pharmaceutical Industry:
NSC 176404 is used as a hepatoprotective agent for its potential to protect the liver from damage caused by toxic substances. Its anti-inflammatory properties also contribute to its therapeutic effects in this application.
Used in Research and Development:
NSC 176404 is used as a subject of study in research to further understand its mechanisms of action and explore its potential applications in medicine. This includes investigating its anti-inflammatory and hepatoprotective properties, as well as identifying any additional therapeutic effects it may possess.

Upstream product

• 1122-91-4 4-bromo-benzaldehyde 
• 27200-79-9 p-bromophenylacetaldehyde 
• 4654-39-1 4-bromophenethanol 
• 17356-08-0 thiourea 
• 61693-77-4 1-(p-bromophenyl)-2,2-dichloroethanol 

Downstream Products

• 73040-61-6 N-[5-(4-bromo-phenyl)-thiazol-2-yl]-acetamide 

Relevant academic research and scientific papers

Dichloromethyllithium: Synthesis and Application in Continuous Flow Mode

A simple and robust procedure for the synthesis and use of thermally unstable dichloromethyllithium in continuous flow mode is described. By utilizing residence times in the range of milliseconds for the generation and electrophilic quench of dichlorometh

FE NANOPARTICLES WITH PPM CONTENTS OF PD, CU AND/OR NI, REACTIONS IN WATER CATALYZED BY THEM

The present application discloses a nanoparticle composition prepared from a mixture comprising: a) a transition metal salt; b) an iron salt; and c) a reducing agent; and methods for the use of such compositions, including the reduction of an organic compound comprising a nitro group to form an organic compound comprising an amine group, the Cu-catalyzed cyclization of an azide and an alkyne (click chemistry) and cross coupling reactions, notably Suzuki-Miyaura reactions. The transition metal salts are in particular Pd, Cu and Ni salts, the content of these metals being typically in the ppm range based on the major constituent Fe in the final products.

Safe and Selective Nitro Group Reductions Catalyzed by Sustainable and Recyclable Fe/ppm Pd Nanoparticles in Water at Room Temperature

As a result of a unique synergy between ligand-free Fe/ppm Pd nanoparticles and PEG-containing designer surfactants, a facile and selective reduction of nitro-containing aromatics and heteroaromatics can be effected in water at room temperature in the presence of NaBH4. This new nanotechnology involves low catalyst loadings, is highly chemoselective, and tolerates a wide variety of functional groups. The process, which includes recycling of the entire aqueous medium, offers a general, environmentally responsible, and notably safe approach to highly valued reductions of nitro-containing compounds.

NOVEL COMPOUNDS

The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R8 are as defined herein.