61693-77-4

Usage

Toxic

can cause skin and eye irritation
Requires proper safety measures and protective equipment when handling

Upstream product

• 7716-86-1 1-(4-bromo-phenyl)-2,2-dichloro-ethanone 
• 21757-86-8 1-(4-bromophenyl)-2,2,2-trichloroethan-1-ol 
• 75-09-2 dichloromethane 
• 1122-91-4 4-bromo-benzaldehyde 

Downstream Products

• 73805-20-6 trans-β-chloro-p-bromostyrene oxide 
• 5216-53-5 1,1-dichloro-2,2-bis(p-bromophenyl)ethane 
• 73040-61-6 N-[5-(4-bromo-phenyl)-thiazol-2-yl]-acetamide 
• 73040-60-5 2-amino-5-(4-bromophenyl)thiazole 

Relevant academic research and scientific papers

Dichloromethyllithium: Synthesis and Application in Continuous Flow Mode

A simple and robust procedure for the synthesis and use of thermally unstable dichloromethyllithium in continuous flow mode is described. By utilizing residence times in the range of milliseconds for the generation and electrophilic quench of dichlorometh

Molecular Rearrangements. 13. Kinetics and Mechanism of Rearrangements of Some Ring-Substituted α-Chlorostyrene Oxides and trans-β-Chlorostyrene Oxides.

The synthesis of certain phenyl-substituted derivatives of the isomeric trans-β-chlorostyrene oxides (6) and α-chlorostyrene oxides (7) are reported.The kinetics of rearrangement of 6 (X = p-CH3, H, p-Br, m-Cl, p-NO2) to phenylchloroacetaldehydes (12) in CCl4 buffered by Na2HPO4 and 7 (X = p-CH3, H, p-NO2) to ω-chloroacetophenones in CCl4 were determined by following the rates of disappearance of the α-chloro epoxide and formation of the α-chloro carbonyl product.These substituent effects at 130 deg C were correlated with ?+ constants, yielding ρ values of-3.5 and -0.57 for the rearrangements of 6 and 7, respectively.In nitrobenzene solvent, the kC6H5NO2/kCCl4 for 6 was 180 and for 7 was 1740, the latter solvent effect attributed to nucleophilic solvent participation.It was concluded that these thermal rearrangements of 6 and 7 occur by disrotatory Cβ-O bond heterolysis to yield the corresponding α-keto carbonium-chloride ion pairs.