73043-17-1

Usage

Structure

It is an oxazolone derivative, featuring a five-membered heterocyclic ring containing oxygen and nitrogen atoms.

Functional Groups

Dichlorophenylmethylene group: Adds to the compound's complexity and potentially confers specific chemical reactivity.
Methyl group: Provides additional diversity in chemical properties and potential reactivity.

Applications

Organic Synthesis: Due to its functional groups, it can serve as a building block in the synthesis of complex organic molecules.
Pharmaceutical Development: Its structure and reactivity may make it valuable in drug discovery and development processes.
Agrochemicals: It might find applications in the synthesis of chemicals used in agriculture, such as pesticides or herbicides.

Safety Considerations

Handle with Caution: Potential hazards and risks may be associated with its use and handling, requiring proper safety protocols.

Potential Risks

Toxicity: Due to the presence of chlorine atoms and the nature of its structure, it might pose health risks if mishandled or improperly used.

Industrial and Research Use

It has potential uses in both industrial processes and academic research, contributing to advancements in various fields.

Upstream product

• 6287-38-3 3,4-dichlorobenzaldehyde 
• 543-24-8 N-acetylglycine 

Downstream Products

• 74168-92-6 5-(3,4-dichloro-benzylidene)-2-methyl-3-thiazol-2-yl-3,5-dihydro-imidazol-4-one 
• 139597-07-2 N-{4-[1-(3,4-Dichloro-phenyl)-meth-(Z)-ylidene]-2-methyl-5-oxo-4,5-dihydro-imidazol-1-yl}-isonicotinamide 
• 138973-22-5 1,4-Bis(5'-(3,4-dichlorobenzylidene)-2'-methyl-4'-imidazolinone-3'-ylamino)phthalazine 
• 119872-10-5 (Z)-2-Acetylamino-3-(3,4-dichloro-phenyl)-acrylic acid 
• 128437-98-9 3-(3,4-dichloro-phenyl)-2-oxo-propionic acid 

Relevant academic research and scientific papers

Mechanistically Guided One Pot Synthesis of Phosphine-Phosphite and Its Implication in Asymmetric Hydrogenation

Although hybrid bidentate ligands are known to yield highly enantioselective products in asymmetric hydrogenation (AH), synthesis of these ligands is an arduous process. Herein, a one pot, atom-economic synthesis of a hybrid phosphine-phosphite (L1) is reported. After understanding the reactivity difference between an O-nucleophile versus C-nucleophile, one pot synthesis of Senphos (L1) was achieved (72 %). When L1 was treated with [Rh], 31P NMR revealed bidentate coordination to Rh. Senphos, in the presence of rhodium, catalyzes the AH of Methyl-2-acetamido-3-phenylacrylate and discloses an unprecedented turn over frequency of 2289, along with excellent enantio-selectivity (92 %). The generality is demonstrated by hydrogenating an array of alkenes. The AH operates under mild conditions of 1–2 bar H2 pressure, at room temperature. The practical relevance of L1 is demonstrated by scaling-up the reaction to 1 g and by synthesizing DOPA, a drug widely employed for the treatment of Parkinson's disease. Computational insights indicate that the R isomer is preferred by 3.8 kcal/mol over the S isomer.

Silver-Promoted Direct Phosphorylation of Bulky C(sp2)-H Bond to Build Fully Substituted β-Phosphonodehydroamino Acids

A general and practical cross-dehydrogenative coupling protocol between readily available trisubstituted α,β-dehydro α-amino carboxylic esters and H-phosphites is described. This C(sp2)-H phosphorylation reaction proceeds with absolute Z-selectivity promoted by silver salt in a radical relay manner. The bulky tetrasubstituted β-phosphonodehydroamino acids were obtained in grams and added new modules to the toolkit for peptide modifications.

Potent, selective tetrahydro-β-carboline antagonists of the serotonin 2B (5HT(2B)) contractile receptor in the rat stomach fundus

A series of potent, selective 5HT(2B) receptor antagonists has been identified based upon yohimbine, with SAR studies resulting in a 1000-fold increase in 5HT(2B) receptor affinity relative to the starting structure (- log K(B)s > 10.0 have been obtained). These high-affinity tetrahydro-β- carboline antagonists are able to discriminate among the 5HT2 family of serotonin receptors, with members of the series showing selectivities of more than 100-fold versus both the 5HT(2A) and 5HT(2C) receptors based upon radioligand binding and functional assays. As the first compounds reported with such selectivity and enhanced receptor affinity, these tetrahydro-β- carboline antagonists are useful tools for elucidating the role of serotonin acting at the 5HT(2B) receptor in normal and disease physiology.