73048-82-5Relevant academic research and scientific papers
Bifunctional amino sulfonohydrazide catalyzed direct asymmetric mannich reaction of cyclic ketimines with ketones: Highly diastereo-and enantioselective construction of quaternary carbon stereocenters
Zhang, Sheng,Li, Lijun,Hu, Yanbin,Zha, Zhenggen,Wang, Zhiyong,Loh, Teck-Peng
, p. 1050 - 1053 (2015)
A bifunctional amino sulfonohydrazide which contains multiple sites for hydrogen bonding with substrates was found to enhance reactivity and enantioselectivity in the direct asymmetric Mannich reaction of N-sulfonyl cyclic ketimines with ketones. In this efficient transformation, not only methyl ketones but also cyclic ketones can be employed to provide a general methodology to construct tetrasubstituted α-amino ester in a stereoselective manner. The synthetic utility of a substituted amino ester product is demonstrated by the synthesis of biologically active spirotetrahydrofuran.
Enantioselective Ester Hydrolysis by Hydroxamic Acids of N-Benzyloxycarbonyl-L-amino Acids or Optically Active Amines in Cetyltrimethylammonium Bromide Micelles
Ihara, Hirotaka,Ono, Shuji,Shosenji, Hideto,Yamada, Kimiho
, p. 1623 - 1625 (2007/10/02)
Hydrolysis of p-nitrophenyl esters of amino acids by hydroxamic acids of N-benzyloxycarbonyl-L-amino acids or optically active amines of L-amino acids in the presence of CTABr micelles showed effective enantioselectivities (D/L = 2.51 and 2.65, respective
