73053-91-5Relevant academic research and scientific papers
Microwave-assisted regioselective synthesis of 2,4-disubstituted imidazoles: Nortopsentin D synthesized by minimal effort
Fresneda,Molina,Sanz
, p. 218 - 221 (2001)
A two step regioselective synthesis of 2,4-disubstituted imidazoles based on the reaction of α-azidoacetyl indoles with carboxylic acids in the presence of tertiary phosphines followed by cyclization of the resulting ketoamides by the action of ammonium acetate under microwave irradiation is described. The method has successfully been applied to the synthesis of the antifungal nortopsentin D [2,4-bis(3-indolyl)imidazole].
First reported propylphosphonic anhydride (T3P) mediated Robinson–Gabriel cyclization. Synthesis of natural and unnatural 5-(3-indolyl)oxazoles
Szabó, Tímea,Dancsó, András,ábrányi-Balogh, Péter,Volk, Balázs,Milen, Mátyás
supporting information, p. 1353 - 1356 (2019/04/27)
In the present work, a propylphosphonic anhydride (T3P) assisted Robinson–Gabriel cyclization of N-acyl-β-oxotryptamines for the synthesis of 2-substituted-5-(3-indolyl)oxazoles has been developed. The reactions proceeded smoothly in acetonitri
Design, synthesis and biological evaluation of novel β-substituted indol-3-yl ethylamido melatoninergic analogues
Iakovou,Varvaresou,Kourounakis,Stead,Sugden,Tsotinis
, p. 147 - 156 (2007/10/03)
A series of new melatonin analogues have been synthesized. Interestingly, two of the new compounds, 11c and 11e, which did not show any appreciable affinity for the melatonin receptor, were found to be potent inhibitors of lipid peroxidation in rat liver microsomes. Analogue 11c, in particular, is a better antioxidant than melatonin.
Synthesis of Oxazolylindole Alkaloids from Tryptamine and Tryptophan by Oxidation with 2,3-Dichloro-5,6-dicyanobenzoquinone
Yoshioka, Tadao,Mohri, Kunihiko,Oikawa, Yuji,Yonemitsu, Osamu
, p. 2252 - 2281 (2007/10/02)
When N-acyl derivatives of tryptamine and L-tryptophan methyl ester were treated with DDQ (2 equiv) in tetrahydrofuran or other anhydrous solvents, four consecutive reactions, dehydrogenation, nucleophilic cyclization, another dehydrogenation, and isomeri
