7306-05-0Relevant articles and documents
SUBSTITUTED PURINE AND 7 - DEAZAPURINE COMPOUNDS AS MODULATORS OF EPIGENETIC ENZYMES
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Page/Page column 249-250, (2012/06/16)
The present invention relates to substituted purine and 7-deazapurine compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating disorders in which DOTl -mediated protein methylation plays a part, such as cancer and neurological disorders, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
Piperazinebenzylamines as potent and selective antagonists of the human melanocortin-4 receptor
Pontillo, Joseph,Tran, Joseph A.,Fleck, Beth A.,Marinkovic, Dragan,Arellano, Melissa,Tucci, Fabio C.,Lanier, Marion,Nelson, Jodie,Parker, Jessica,Saunders, John,Murphy, Brian,Foster, Alan C.,Chen, Chen
, p. 5605 - 5609 (2007/10/03)
SAR studies of a series of piperazinebenzylamines resulted in the discovery of potent antagonists of the human melanocortin-4 receptor. Compounds 11c, 11d, and 11l, which had Ki values of 21, 14, and 15 nM, respectively, possessed low efficacy