73082-07-2

Basic information

• Product Name: 3,4-diphenyl-pyrrolidine
• Synonyms: 3,4-diphenyl-pyrrolidine
• CAS NO: 73082-07-2
• Molecular Weight: 223.318
• Mol File: 73082-07-2.mol

Chemical Properties

• CAS DataBase Reference: 3,4-diphenyl-pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-diphenyl-pyrrolidine(73082-07-2)
• EPA Substance Registry System: 3,4-diphenyl-pyrrolidine(73082-07-2)

Safety Data

• Hazardous Substances Data: 73082-07-2(Hazardous Substances Data)

Upstream product

• 118989-04-1 3,4-diphenyl-trans-N-(1'-hydroxy-2'-butyl)-pyrrolidine 
• 4209-77-2 N-Benzyl-3,4-diphenylpyrrolidine 
• 118988-98-0 1-(1-tert-Butoxymethyl-propyl)-3,4-diphenyl-pyrrolidine 
• 118989-04-1 2-(3,4-Diphenyl-pyrrolidin-1-yl)-butan-1-ol 
• 103-30-0 (E)-1,2-diphenyl-ethene 
• 4209-77-2 1-benzyl-3,4-diphenylpyrrolidine 

Relevant articles and documents

Convenient method for the synthesis of chiral α,α-diphenyl-2-pyrrolidinemethanol

A simplified, convenient synthesis of chiral α,α-diphenyl-2-pyrrolidine-methanol involving one step N-and O-protection of S-proline using ethylchloroformate followed by Grignard addition-alkaline hydrolysis (KOH/CH3OH) is described.

The Use of the β-Amino-Alcohol-N-Oxide Derivatives in the Synthesis of 2,3 or 4-Alkyl Substituted NH Pyrrolidines

Nonstabilized azomethine ylides generated from the various β-amino alcohols N-oxides 13, 17, 23 and 24 undergo cycloaddition reactions with unactivated alkenes to afford the corresponding pyrrolidines 14a-g, 18a-g, 25 und 27 in moderate to good yields.These compounds are precursors of NH pyrrolidines substituted in position 2, 3 or 4.

A 3+2 CYCLOADDITION ROUTE TO N-H PYRROLIDINES DEVOID OF ELECTRON-WITHDRAWING GROUPS

N-H pyrrolidines are obtained from intermolecular 3+2 cycloaddition reactions between nonactivated olefins and ylide generated from amine N-oxide 1 structurally designed in such a way as to allow easy dealkylation of the cycloadduct.

Production of 3-pyrrolin-2-ones

Pyrrolidin-2-ones are produced by hydrogenation of 3-pyrrolin-2-ones, which latter compounds could not prior to this invention be easily obtained. These 3-pyrrolin-2-ones with various substituents are produced by ring closure of N-aroylmethyl-acetamides.