4209-77-2

Basic information

• Product Name: N-Benzyl-3,4-diphenylpyrrolidine
• CAS NO: 4209-77-2
• Molecular Weight: 313.442
• Mol File: 4209-77-2.mol

Chemical Properties

• CAS DataBase Reference: N-Benzyl-3,4-diphenylpyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Benzyl-3,4-diphenylpyrrolidine(4209-77-2)
• EPA Substance Registry System: N-Benzyl-3,4-diphenylpyrrolidine(4209-77-2)

Safety Data

• Hazardous Substances Data: 4209-77-2(Hazardous Substances Data)

Upstream product

• 102594-38-7 1-benzyl-3,4-diphenyl-pyrrolidine-2,5-dione 
• 100-44-7 benzyl chloride 
• 118989-04-1 2-(3,4-Diphenyl-pyrrolidin-1-yl)-butan-1-ol 
• 103-30-0 (E)-1,2-diphenyl-ethene 
• 7584-72-7 meso-2,3-diphenylsuccinic acid 
• 102594-38-7 rans-N-benzyl-3,4-diphenylsuccinimide 
• 65950-40-5 N,N-bis(tosylmethyl)benzylamine 
• 118989-04-1 3,4-diphenyl-trans-N-(1'-hydroxy-2'-butyl)-pyrrolidine 
• 100-39-0 benzyl bromide 
• 3059-23-2 dl-Diethyl 2,3-diphenylsuccinate 
• 1225-13-4 (2S,3S)-(dl)-2,3-diphenylsuccinic acid 
• 100-46-9 benzylamine 
• 118988-98-0 1-(1-tert-Butoxymethyl-propyl)-3,4-diphenyl-pyrrolidine 
• 111184-83-9 N,N-bis<(benzotriazol-1-yl)methyl>benzylamine 

Downstream Products

• 122764-07-2 1-benzyl-1-methyl-3,4-diphenyl-pyrrolidinium; bromide 
• 73082-07-2 3,4-diphenyl-trans-pyrrolidine 
• 73082-07-2 3,4-diphenyl-pyrrolidine 

Relevant articles and documents

Convenient synthetic methods to C2 symmetric 3,4-diphenylpyrrolidines

Convenient methods of synthesis of racemic and optically pure 3,4- diphenylpyrrolidine derivatives, involving oxidative coupling of ethyl phenylacetate using TiCl4/Et3N and reduction of the dl-2,3-diphenylsuccinic acid or the corresponding cyclic imide with NaBH4/I2 reagent in crucial steps, are described.

The synthesis of 3,5-Di- and 3,5,5-trisubstituted-1,3-oxazolidines from primary amines and carbonyl compounds

A variety of 3,5-substituted 1,3-oxazolidines are synthesized from primary amines by a novel, two step sequence.

Synthesis of 3-arylpyrrolidines by cycloadditions of N,N-bis(benzotriazolylmethyl)amines to styrenes

A novel synthesis of 3-arylpyrrolidines (3a-m) via the cycloaddition of bis-benzotriazole derivatives to styrenes is described.

Convenient methods for the reduction of amides, nitriles, carboxylic esters, acids and hydroboration of alkenes using NaBH4/I2system

Reaction of amides with NaBH4-I2 system in THF gives the corresponding amines in 70-76% yields. Reduction of nitriles yields the corresponding amines in 70-75% yields. The I2/NaBH4 system is useful in the hydrocarboration of olefins and the corresponding alcohols are obtained in 78-92% yields after H2O2/OH- oxidation. The reagent system is also useful for the reduction of carboxylic esters and acids to the corresponding alcohols in 60-90% yields.

The Use of the β-Amino-Alcohol-N-Oxide Derivatives in the Synthesis of 2,3 or 4-Alkyl Substituted NH Pyrrolidines

Nonstabilized azomethine ylides generated from the various β-amino alcohols N-oxides 13, 17, 23 and 24 undergo cycloaddition reactions with unactivated alkenes to afford the corresponding pyrrolidines 14a-g, 18a-g, 25 und 27 in moderate to good yields.These compounds are precursors of NH pyrrolidines substituted in position 2, 3 or 4.

A 3+2 CYCLOADDITION ROUTE TO N-H PYRROLIDINES DEVOID OF ELECTRON-WITHDRAWING GROUPS

N-H pyrrolidines are obtained from intermolecular 3+2 cycloaddition reactions between nonactivated olefins and ylide generated from amine N-oxide 1 structurally designed in such a way as to allow easy dealkylation of the cycloadduct.