73096-40-9

Usage

Uses

Used in Chemical Synthesis:
5-(2-Iodophenyl)-1H-tetrazole is used as a reagent for the synthesis of more complex molecules. Its unique structure, featuring the iodine atom and the tetrazole ring, allows it to participate in various chemical reactions, making it a versatile building block in organic chemistry.
Used in Pharmaceutical Industry:
5-(2-Iodophenyl)-1H-tetrazole is used as a key intermediate in the development of pharmaceutical compounds. Its properties can be exploited to create new drugs with potential therapeutic applications, particularly in the areas of medicinal chemistry and drug discovery.
Used in Research and Development:
5-(2-Iodophenyl)-1H-tetrazole is used as a research tool in academic and industrial laboratories. Its reactivity and structural features make it an interesting subject for studying reaction mechanisms, exploring new synthetic routes, and understanding the properties of related compounds.
Used in Material Science:
5-(2-Iodophenyl)-1H-tetrazole is used as a component in the development of new materials with specific properties. Its incorporation into polymers or other materials can lead to the creation of novel materials with applications in various industries, such as electronics, coatings, or adhesives.

InChI:InChI=1/C7H5IN4/c8-6-4-2-1-3-5(6)7-9-11-12-10-7/h1-4H,(H,9,10,11,12)

Upstream product

• 624-84-0 formic acid hydrazide 
• 4387-36-4 2-iodobenzonitrile 

Relevant academic research and scientific papers

N-Heterocycle (tetrazole)-stabilized pseudocyclic λ3-iodane: Synthesis and reactivity

An N-heterocycle (tetrazole)-stabilized pseudocyclic λ3-iodane was synthesized and its thermal stability and redox activity were studied. Simultaneous thermogravimetric analysis and differential scanning calorimetry revealed that the polyvalent iodine compound started to degrade at 127 °C and showed a notable exothermic decomposition peak at 147 °C, which was markedly more pronounced than the parent tetrazole with monovalent iodine. The reduction potential was determined by cyclic voltammetry to be ?0.38 V vs AgNO3|Ag in dimethyl sulfoxide at a scan rate of 0.02 V/s. The oxidative power of the polyvalent iodine compound was demonstrated by conducting oxidation of thioanisole to sulfoxide and oxidative dimerization of thiobenzamide to 3,5-diphenyl-1,2,4-thiadiazole.

1,3-Dipolar cycloaddition: Click chemistry for the synthesis of 5-substituted tetrazoles from organoaluminum azides and nitriles

Cheap and safe: Conventional methods to prepare tetrazoles employ dangerous, toxic reagents. A new route to these heterocycles (see scheme) uses inexpensive and nontoxic dialkyl aluminum azides. The cycloaddition occurs under mild conditions and tolerates a variety of functional groups. The low cost and ecocompatibility make this process attractive for large-scale preparation. (Chemical Equation Presented).

A Practical Synthesis of 5-Substituted Tetrazoles.

Nitrosation of N-formyl amidrazones 8a-g with sodium nitrite - aqueous hydrochloric acid gives tetrazoles 10a-g in good yields.