730971-29-6

Basic information

• Product Name: N-[4-chloro-7-(5-cyano-2-methoxy-phenyl)-isoquinolin-1-yl]-guanidine
• CAS NO: 730971-29-6
• Molecular Weight: 351.795
• Mol File: 730971-29-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[4-chloro-7-(5-cyano-2-methoxy-phenyl)-isoquinolin-1-yl]-guanidine(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-chloro-7-(5-cyano-2-methoxy-phenyl)-isoquinolin-1-yl]-guanidine(730971-29-6)
• EPA Substance Registry System: N-[4-chloro-7-(5-cyano-2-methoxy-phenyl)-isoquinolin-1-yl]-guanidine(730971-29-6)

Safety Data

• Hazardous Substances Data: 730971-29-6(Hazardous Substances Data)

Upstream product

• 223671-13-4 7-bromo-1,4-dichloroisoquinoline 
• 612833-37-1 (5-cyano-2-methoxyphenyl)boronic acid 
• 50-01-1 guanidine hydrochloride 
• 730971-24-1 3-(1,4-dichloro-isoquinolin-7-yl)-4-methoxy-benzonitrile 

Relevant articles and documents

Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 3: 1-Isoquinolinylguanidines

A series of 1-isoquinolinylguanidines are shown to be potent inhibitors of uPA with selectivity over tPA and plasmin. Potency is enhanced by the presence of a 4-halo and a 7-aryl substituent, particularly when substituted by a 3-carboxylic acid group. Compound 13j (UK-356,202) combines excellent potency and selectivity, and has been selected as a candidate for clinical evaluation.