730984-83-5

Upstream product

• 17131-52-1 3-(4-methoxyphenoxy)-1,2-propanediol 
• 150-76-5 4-methoxy-phenol 
• 115314-14-2 (2s)-(+)-glycidyl 3-nitrobenzenesulfonate 
• 123-31-9 hydroquinone 

Downstream Products

• 57526-81-5 prenalterol 
• 208459-22-7 (2S)-1-Amino-3-(4-hydroxy-phenoxy)-propan-2-ol 
• 209180-77-8 4-{(S)-3-[2-(4-Amino-phenyl)-ethylamino]-2-hydroxy-propoxy}-phenol 
• 391901-42-1 tert-butyl 4-[(2,4-dioxo-1,3-thiazolidin-5-yl)amino]phenethyl[(2 S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]carbamate 
• 391902-05-9 tert-butyl 4-[(4-bromobenzyl)amino]phenethyl[(2 S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]carbamate 
• 391901-41-0 tert-butyl 4-aminophenethyl[(2 S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]carbamate 

Relevant academic research and scientific papers

A simplified template approach towards the synthesis of a potent beta-3 adrenoceptor agonist at the human receptor

A simplified template approach was used to delineate the structural requirements for high potency and intrinsic activity of aryloxypropanolamines as agonists at the human beta-3 adrenoceptor. The information generated was used to prepare selective beta-3 adrenoceptor agonists.

Effective synthesis of non-racemic prenalterol based on spontaneous resolution of 3-(4-hydroxyphenoxy)propane-1,2-diol

Spontaneous resolution of rac-3-(4-hydroxyphenoxy)propane-1,2-diol has been successfully used in the synthesis of both enantiomers of chiral drug prenalterol.

Potent, selective aminothiazolidinediones agonists of the human β3 Adrenergic receptor

A cloned human β3 adrenergic receptor assay was used to identify potent and selective β3 agonists. The thiazolidinedione moiety has been identified as a new pharmacophore for the human β3 adrenergic receptor. The versatility of the thiazolidinedione pharmacophore was demonstrated in both the arylethanolamine and phenylpropanolamine families of β3 agonists, where potent and selective compounds have been synthesized. Thiazolidinedione 20, a potent and selective human β3 agonist, increased thermogenesis and lowered plasma glucose levels in the db/db mice.