A simplified template approach towards the synthesis of a potent beta-3 adrenoceptor agonist at the human receptor

Article abstract of DOI:10.1016/S0960-894X(96)00603-8

A simplified template approach was used to delineate the structural requirements for high potency and intrinsic activity of aryloxypropanolamines as agonists at the human beta-3 adrenoceptor. The information generated was used to prepare selective beta-3 adrenoceptor agonists.