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4-oxo-3-phenyl-3,4-dihydroquinazoline-2-carbonitrile is a complex organic compound with the molecular formula C15H10N2O. It is a derivative of quinazoline, a heterocyclic compound with a fused benzene ring and a pyrimidine ring. This specific compound features a carbonitrile group (-CN) at the 2-position, a phenyl group (C6H5) at the 3-position, and a 4-oxo group (C=O) at the 4-position. The 3,4-dihydro part of the name indicates that there are two hydrogen atoms added to the quinazoline ring, making it partially saturated. 4-oxo-3-phenyl-3,4-dihydroquinazoline-2-carbonitrile is of interest in medicinal chemistry due to its potential applications as a building block for the synthesis of various pharmaceuticals and agrochemicals. It is typically synthesized through a multi-step process involving the reaction of anthranilic acid with a suitable arylamine, followed by cyclization and oxidation steps. The compound's properties, such as its reactivity and stability, can be influenced by the presence of substituents on the phenyl ring and the overall structure of the molecule.

731-51-1

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731-51-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 731-51-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,3 and 1 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 731-51:
(5*7)+(4*3)+(3*1)+(2*5)+(1*1)=61
61 % 10 = 1
So 731-51-1 is a valid CAS Registry Number.

731-51-1Relevant academic research and scientific papers

One-step conversion of 2-Amino- N ′-arylbenzamidines into 3-aryl-4-imino-3,4-dihydroquinazoline-2-carbonitriles using 4,5-dichloro-1,2,3- dithiazolium chloride

Mirallai, Styliana I.,Manos, Manolis J.,Koutentis, Panayiotis A.

, p. 9906 - 9913 (2013/10/22)

2-Amino-N′-arylbenzamidines react with 4,5-dichloro-1,2,3- dithiazolium chloride (Appel salt) in the presence of Huenig's base (2 equiv) to give in one step 3-aryl-4-imino-3,4-dihydroquinazoline-2-carbonitriles in 53-81% yields. Nine examples are presented along with the single-crystal X-ray structure of 4-imino-3-phenyl-3,4-dihydroquinazoline-2-carbonitrile. Furthermore, the behavior of the latter toward both acid and base hydrolysis is investigated. All new compounds are fully characterized, and a mechanistic rationale for the formation of the iminoquinazolines is provided.

ortho-Lithiophenyl isocyanide: A versatile precursor for 3H-quinazolin-4-ones and 3H-quinazolin-4-thiones

Lygin, Alexander V.,De Meijere, Armin

supporting information; experimental part, p. 389 - 392 (2009/09/05)

(Chemical Equation Presented) ortho-Lithiophenyl isocyanide has been generated from ortho-bromophenyl isocyanide and successfully employed toward the synthesis of 2-substituted phenyl Isocyanides as well as 2,3-disubstituted 3H-quinazoline-4-ones and 3H-q

Reactions of Isocyanates with Methyl N-(Cyanothioformyl)anthranilate

Deck,Papadopoulos,Smith

, p. 885 - 893 (2007/10/03)

The triethylamine-catalyzed reactions of methyl N-(cyanothioformyl)anthranilate (1) with isocyanates result in cyclization involving the cyano group to form methyl 2-(4-imino-2-oxo-3-substituted-5-thioxoimidazolidin-1-yl)benzoates (4). Ring closure at the ester carbonyl to form 3-aryl-3,4-dihydro-4-oxoquinazoline-2-carbonitriles (8) is observed when the S-methyl derivative of 1 is allowed to react with aromatic amines.

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