7311-64-0

Usage

Chemical Properties

white to light yellow crystal powder

InChI:InChI=1/C5H3BrO2S/c6-3-1-2-9-4(3)5(7)8/h1-2H,(H,7,8)/p-1

Upstream product

• 872-31-1 3-Bromothiophene 
• 109-72-8 n-butyllithium 
• 60-29-7 diethyl ether 
• 3140-93-0 2,3-dibromothiophen 
• 930-96-1 3-bromo-2-thiophenecarboxaldehyde 
• 42877-08-7 1-(3-bromothiophen-2-yl)ethanone 
• 124-38-9 carbon dioxide 
• 22288-78-4 Methyl 3-aminothiophene-2-carboxylate 
• 26137-08-6 methyl 3-bromothiophene-2-carboxylate 

Downstream Products

• 7311-68-4 3,5-dibromothiophene-2-carboxylic acid 
• 1451-95-2 thiophene-2,3-dicarboxylic acid 
• 25796-68-3 3-bromo-thiophene-2-carbonyl chloride 
• 26137-08-6 methyl 3-bromothiophene-2-carboxylate 
• 13999-11-6 5-deuteriothiophene-2-carboxylic acid 
• 101306-24-5 3-deuteriothiophene-2-carboxylic acid 
• 816418-31-2 3-bromothiophene-2-carboxylic acid benzylamide 
• 816418-30-1 3-bromothiophene-2-carboxylic acid methylamide 
• 70260-17-2 3-bromo-2-hydroxymethyl-thiophene 
• 452910-56-4 1-(3-bromo-thiophene-2-carboxylic acid)-2-(4-toluenesulfonyl)-hydrazine 
• 1144508-53-1 (R)-(3-bromothiophen-2-yl)(2,4-dibenzylpiperazin-1-yl)methanone 
• 1144508-56-4 (R)-tert-butyl 3-benzyl-4-(3-bromothiophene-2-carbonyl)piperazine-1-carboxylate 
• 872-31-1 3-Bromothiophene 
• 1334392-84-5 4-[2-(3-chlorophenoxymethyl)thiophen-3-yl]piperidine trifluoroacetate 

Relevant academic research and scientific papers

7-(MORPHOLINYL)-2-(N-PIPERAZINYL) METHYL THIENO [2, 3-C] PYRIDINE DERIVATIVES AS ANTICANCER DRUGS

The present invention relates to novel series of substituted 7-(morpholinyl)-2-(N-piperazinyl)-methyl thieno [2, 3-c] pyridines of the following structure of formula I. Where in R1, R2, R3 and R4 are defined.

Efficient synthesis of novel thieno[3,2-b]-, [2,3-c]- and [3,2-c]pyridones by Sonogashira coupling of bromothiophenes with terminal alkynes and subsequent intramolecular C-N bond-forming reaction

The coupling of bromothiophenes with terminal alkynes using triethylamine or diisopropyl amine under Sonogashira conditions (PdCl2(PPh 3)2, CuI) followed by subsequent addition of amines or ammonium to the intermediate thienyl acetylenes represents a novel access to a wide range of thieno[3,2-b]-, [2,3-c]-, and [3,2-c]pyridones under basic conditions and in excellent yields.

ORGANIC SEMICONDUCTOR MATERIAL

The present invention relates to a novel compounds useful as organic semiconductor material, and semiconductor devices containing said organic semiconductor material.

Thienopyrrolyl dione end-capped oligothiophene ambipolar semiconductors for thin film- and light emitting transistors

The design, synthesis and structure-property investigation of a new thienopyrrolyl dione substituted oligothiophene material showing reduced band gap energy, low lying LUMO energy level and ambipolar semiconducting behaviour is described.

Novel heterocyclic urea derivatives and their use as dopamine D3 receptor ligands

The invention relates to heterocyclic substituted urea derivatives that display selective binding to dopamine D3 receptors. In another aspect, the invention relates to a method for treating central nervous system disorders associated with the dopamine D3 receptor activity in a patient in need of such treatment comprising administering to the subject a therapeutically effective amount of said compounds for alleviation of such disorder. The central nervous system disorders that may be treated with these compounds include Psychotic Disorders, Substance Dependence, Substance Abuse, Dyskinetic Disorders (e.g. Parkinson's Disease, Parkinsonism, Neuroleptic-Induced Tardive Dyskinesia, Gilles de la Tourette Syndrome and Huntington's Disease), Dementia, Anxiety Disorders, Sleep Disorders, Circadian Rhythm Disorders and Mood Disorders. The subject invention is also directed towards processes for the preparation of the compounds described herein as well as methods for making and using the compounds as imaging agents for dopamine D3 receptors.

Synthesis of novel chiral thiophene-, benzothiophene- and benzofuran-oxazoline ligands and their use in the enantioselective Pd-catalyzed allylation

Novel thiophene, benzothiophene and benzofuran-oxazoline ligands 6-11 containing a diphenylphosphino group at different positions of the heterocyclic skeleton have been prepared and used in the enantioselective allylation. The advantage of these new ligands is their easy accessibility and their high reactivity. The best results were obtained with ligand 9 to give the product 13 in 97.0% ee with 92% yield in 2 hours at 0°C.

Phosphorylamides, their preparation and use

A phosphorylamide derivative represented by the general formula (I): STR1 wherein R represents an amino group that may be substituted, or a salt thereof, possesses potent antibacterial activity against Helicobacter bacterium, especially Helicobacter pylori, and is useful for prevention or treatment of digestive diseases caused by Helicobacter bacterium, solely or in combination with an antacid or an acid secretion inhibitor.

Synthesis and antitumour activity of new derivatives of flavone-8- acetic acid (FAA). Part 31): 2-Heteroaryl derivatives

A range of 14 derivatives of flavone-8-acetic acid (FAA) with a heterocyclic substituent in place of the 2-phenyl group have been prepared and their anti-tumour activity evaluated in vitro against a panel of human and murine tumour cell lines and in vivo against MAC 15A. Some of the compounds, notably 2c,d and s, showed significant in vivo activity and these require further studies in order to evaluate their potential for development.

A FACILE SYNTHESIS OF HOGHLY FUNCTIONALIZED UNSYMMETRICAL HETEROBIARYLS UTILIZING THE INTRAMOLECULAR ULLMANN COUPLING REACTION DIRECTED BY SALICYL ALCOHOL AS A TEMPLATE

The cyclic heterobiaryls (3) containing a thenoyl of furoyl group were synthesized in good yields by regioselective acylations of salicyl alcohol (1), followed by the intramolecular Ullmann coupling reaction of the diesters (2).The cleavage of the two est