7311-79-7

Basic information

• Product Name: dimethyl 3-bromothiophene-2,5-carboxylate
• CAS NO: 7311-79-7
• Molecular Weight: 279.111
• Mol File: 7311-79-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: dimethyl 3-bromothiophene-2,5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl 3-bromothiophene-2,5-carboxylate(7311-79-7)
• EPA Substance Registry System: dimethyl 3-bromothiophene-2,5-carboxylate(7311-79-7)

Safety Data

• Hazardous Substances Data: 7311-79-7(Hazardous Substances Data)

Upstream product

• 872-31-1 3-Bromothiophene 
• 124-38-9 carbon dioxide 
• 74-88-4 methyl iodide 

Relevant articles and documents

Ag(I)-Catalyzed C-H Carboxylation of Thiophene Derivatives

CO2utilization is an attractive aspect as it allows the direct conversion of CO2into valuable chemicals. In this regard, direct incorporation of CO2into the C-H bond of heteroaromatic compounds is important due to the ubiquitous structural motifs of the heteroaromatic carboxylic acids. Herein, we report the Ag-catalyzed C-H carboxylation of thiophene derivatives. This new catalytic system involving a phosphine ligand and lithiumtert-butoxide enables the direct carboxylation of thiophenes under mild reaction conditions. Experimental studies revealed that the use oftert-butyl alkoxide is critical for the exergonic formation of an arylsilver intermediate, and the results were further supported by density functional theory calculations.