7311-95-7

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
Ethyl-2-amino-benzo(b)thiophene-3-carboxylate is used as a key building block for the synthesis of new drugs with enhanced biological activities. Its unique molecular structure allows for the development of therapeutic agents with potential applications in various medical fields.
Used in Anticancer Applications:
Ethyl-2-amino-benzo(b)thiophene-3-carboxylate is used as an anticancer agent, demonstrating potential in the treatment of various types of cancer. Its pharmacological properties contribute to the inhibition of tumor growth and progression, making it a promising candidate for further research and development in oncology.
Used in Anti-inflammatory Applications:
Ethyl-2-amino-benzo(b)thiophene-3-carboxylate is used as an anti-inflammatory agent, exhibiting potential in the management of inflammation-related conditions. Its ability to modulate inflammatory pathways and reduce inflammation makes it a valuable compound in the development of new anti-inflammatory drugs.
Used in Antimicrobial Applications:
Ethyl-2-amino-benzo(b)thiophene-3-carboxylate is used as an antimicrobial agent, showing potential in the treatment of bacterial infections. Its ability to target and eliminate harmful microorganisms makes it a promising candidate for the development of new antimicrobial drugs.

InChI:InChI=1/C11H11NO2S/c1-2-14-11(13)9-7-5-3-4-6-8(7)15-10(9)12/h3-6H,2,12H2,1H3

Upstream product

• 7311-77-5 2-acetylamino-benzo[b]thiophene-3-carboxylic acid ethyl ester 
• 5919-29-9 ethyl 2-acetylamino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 
• 108-94-1 cyclohexanone 
• 105-56-6 ethyl 2-cyanoacetate 
• 4506-71-2 ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 
• 547706-52-5 2-(cyclopropanecarbonyl-amino)-benzo[b]thiophene-3-carboxylic acid ethyl ester 

Downstream Products

• 18774-49-7 benzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one 
• 117516-91-3 N-(3-carbethoxy<1>benzothien-2-yl)-N'-benzoylthiourea 
• 934394-07-7 2-mercapto-3-(4-trifluoromethoxy-phenyl)-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one 
• 934394-03-3 2-mercapto-3-phenyl-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one 
• 40142-92-5 3-chloro-8-thia-4,6-diazatricyclo[7.4.0.0[2,7]]trideca-1⁽⁹⁾,2,4,6,10,12-hexaene 
• 18774-49-7 8-thia-4,6-diazatricyclo[7.4.0.0[2,7]]trideca-1⁽⁹⁾,2⁽⁷⁾,3,5,10,12-hexaen-3-ol 
• 901370-33-0 ethyl 2-benzenesulphonylaminobenzo[b]thiophene-3-carboxylate 
• 1372985-52-8 ethyl 2-[bis-(benzenesulphonyl)amino]benzo[b]thiophene-3-carboxylate 

Relevant academic research and scientific papers

Computer-aided identification, synthesis and evaluation of substituted thienopyrimidines as novel inhibitors of HCV replication

A structure-based virtual screening technique was applied to the study of the HCV NS3 helicase, with the aim to find novel inhibitors of the HCV replication. A library of ～450000 commercially available compounds was analysed in silico and 21 structures were selected for biological evaluation in the HCV replicon assay. One hit characterized by a substituted thieno-pyrimidine scaffold was found to inhibit the viral replication with an EC50value in the sub-micromolar range and a good selectivity index. Different series of novel thieno-pyrimidine derivatives were designed and synthesised; several new structures showed antiviral activity in the low or sub-micromolar range.

A simple synthesis of alkyl 2-aminobenzo[ b ]thiophene-3-carboxylates via an unexpected dehydrogenation of alkyl 2-amino-4,5,6,7-tetrahydrobenzo[ b ]thiophene-3-carboxylates

A simple method for the preparation of alkyl 2-aminobenzo[b]thiophene-3-carboxylates is described. Alkyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylates, generated from the Gewald three-component reaction between cyclohexanones, alkyl cyanoacet

A simple synthesis of alkyl 2-aminobenzo[ b ]thiophene-3-carboxylates via an unexpected dehydrogenation of alkyl 2-amino-4,5,6,7-tetrahydrobenzo[ b ]thiophene-3-carboxylates

A simple method for the preparation of alkyl 2-aminobenzo[b]thiophene-3-carboxylates is described. Alkyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylates, generated from the Gewald three-component reaction between cyclohexanones, alkyl cyanoacetates and sulfur, undergo dehydrogenation in benzonitrile under an air atmosphere to afford alkyl 2-aminobenzo[b]thiophene-3-carboxylates in good to excellent yields.

TRICYCLIC BENZO[4,5]THIENO-[2,3-D]PYRIMIDINE-4-YL-AMIN DERIVATIVES, THEIR SALTS, PROCESS FOR PRODUCING THE COMPOUNDS AND THEIR PHARMACEUTICAL USE

The invention relates to novel tricyclic benzo[4,5]thieno-[2,3-d]pyrimidine-4-yl-amin derivatives, as well as their pharmaceutically acceptable salts. The subject of the invention too the process for producing the compounds and their use as a pharmaceutic

TRICYCLIC BENZO[4,5]THIENO-[2,3-D]PYRIMIDINE-4-YL-AMIN DERIVATIVES, THEIR SALTS, PROCESS FOR PRODUCING THE COMPOUNDS AND THEIR PHARMACEUTICAL USE

The invention relates to novel tricyclic benzo[4,5]thieno-[2,3-d]pyrimidine-4-yl-amin derivatives, as well as their pharmaceutically acceptable salts. The subject of the invention too the process for producing the compounds and their use as a pharmaceutic

BENZOTHIENO’2,3-D! PYRIMIDINE COMPOUNDS AS INHIBITORS OF TYROSINE KINASE ACTIVITIES OF THE EPIDERMAL GROWTH FACTOR RECEPTORS (EGFRS) FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES

This invention relates to novel compounds of formula (I) and processes for their preparation, their use for of treating diseases, particularly hyperproliferative diseases such as cancer, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly hyperproliferative diseases such as cancer. Wherein m is 0, 1 or 2; R3 is *-O(CH2)n AR, wherein Ar is phenyl, thienyl, furyl, pyrrolyl, thiazolyl, oxazolyl, imidazolyl, pyridyl, pyrimidyl od pyridazinyl, wherein Ar can optionally be substituted.

NF-KB INHIBITORS

The present invention provides novel compounds and methods for using them to treat diseases with aminothiophene inhibitors of IKK-β phosphorylation of IκB. In so doing these aminothiophene inhibitors block pathological activation of transcription factor N

Fused thiophene compounds and medicinal use thereof

A condensed thiophene compound of the formula (I) wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof and hydrates thereof. The compound of the formula (I) of the present invention is useful as a novel antipsychotic agent which is effective for both positive symptoms and negative symptoms of schizophrenia, which is associated with less side effects such as extrapyramidal motor disorder and the like and which is less associated with serious side effects such as agranulocytosis and the like. In addition, this compound is also useful as a therapeutic agent of Alzheimer's disease and manic-depressive illness.