73119-33-2Relevant academic research and scientific papers
1,3-Dithianes as Acyl Anion Equivalents in Pd-Catalyzed Asymmetric Allylic Substitution
Yao, Kun,Liu, Delong,Yuan, Qianjia,Imamoto, Tsuneo,Liu, Yangang,Zhang, Wanbin
, p. 6296 - 6299 (2016)
A Pd-catalyzed asymmetric allylic substitution with 1,3-dithianes as acyl anion equivalents has been developed in high yields and excellent enantioselectivities. The reaction was performed on a gram scale, and the corresponding alkylated products were con
Difunctionalization of Alkynones by Base-Mediated Reaction with α,α-Dithioketones
Yang, Yajie,Cheng, Lu,Wang, Mengdan,Yin, Liqiang,Feng, Ye,Wang, Chengyu,Li, Yanzhong
supporting information, p. 5339 - 5343 (2021/07/26)
A novel 1,2-difunctionalization of alkynones via an umpolung strategy for the synthesis of tetrasubstituted olefins has been developed. This procedure is realized by a formal C-C σ-bond cleavage reaction of cyclic α,α-dithioketones and subsequent deprotection. Notable features of this approach include excellent yields, mild reaction conditions, a broad substrate scope, and operational simplicity.
Weinreb amide based building blocks for convenient access to 1,1-diarylethenes and isocombretastatin analogues
Balasubramaniam, Sivaraman,Kommidi, Harikrishna,Aidhen, Indrapal Singh
supporting information; experimental part, p. 2683 - 2686 (2011/06/19)
A successful strategy based on the synthetic equivalent containing Weinreb amide functionality for the convenient access to 1,1-diarylethenes in general and for the isocombretastatin analogues in particular has been developed from the commercially available glyoxalic acid. The convenience with which the structural variations can be made in assembling the aryl residues shows generality associated with the developed strategy. The intermediates also provide access to 1,2,2-triarylethanones, represented by the synthesis of advanced intermediate of tamoxifen.
