122334-36-5

Basic information

• Product Name: 4,N-DIMETHYL-N-METHOXYBENZAMIDE
• Synonyms: 4,N-DIMETHYL-N-METHOXYBENZAMIDE;N,4-DIMETHOXY-N-METHYLBENZAMIDE;N-methoxy-N,4-dimethylbenzamide
• CAS NO: 122334-36-5
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.22
• Mol File: 122334-36-5.mol
• Article Data: 27

Chemical Properties

• Boiling Point: 318.4 °C at 760 mmHg
• Flash Point: 146.3 °C
• Appearance: /
• Density: 1.07 g/cm³
• Vapor Pressure: 0.000363mmHg at 25°C
• Refractive Index: 1.523
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4,N-DIMETHYL-N-METHOXYBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,N-DIMETHYL-N-METHOXYBENZAMIDE(122334-36-5)
• EPA Substance Registry System: 4,N-DIMETHYL-N-METHOXYBENZAMIDE(122334-36-5)

Safety Data

• Hazardous Substances Data: 122334-36-5(Hazardous Substances Data)

Usage

Uses

N-Methoxy-N,4-dimethylbenzamide is used in the synthesis of Fingolimod (F342045)

InChI:InChI=1/C10H13NO2/c1-8-4-6-9(7-5-8)10(12)11(2)13-3/h4-7H,1-3H3

Upstream product

• 99-94-5 p-Toluic acid 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 874-60-2 4-methyl-benzoyl chloride 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 201230-82-2 carbon monoxide 
• 106-38-7 para-bromotoluene 
• 93131-73-8 4-tolyl perfluorobutanesulfonate 
• 13939-06-5 molybdenum hexacarbonyl 
• 589-18-4 4-Methylbenzyl alcohol 
• 624-31-7 4-tolyl iodide 
• 10347-11-2 4-(methylbenzoyl)imidazoline 
• 1062512-43-9 C₆H₁₈N₃O₃P 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 223570-55-6 N-methoxy-N-methyl-2-pyridyl urethane 

Downstream Products

• 724452-72-6 4-(bromomethyl)-N-methoxy-N-methylbenzamide 
• 51490-06-3 1,2-di-p-tolyl-ethanone 
• 52920-19-1 2-(4-methylbenzoyl)-benzaldehyde 
• 64591-47-5 2-methoxy-1-(4-methylphenyl)ethan-1-one 
• 18370-11-1 N-methyl-p-methylbenzamide 
• 589-18-4 4-Methylbenzyl alcohol 
• 5456-97-3 N-butyl-4-methylbenzamide 
• 938461-09-7 2-bromo-N-methoxy-N,4-dimethylbenzamide 
• 36734-50-6 1‐(4‐methylphenyl)‐2‐(phenylsulfanyl)ethanone 
• 24437-54-5 1‐(4‐methylphenyl)‐2‐(methylsulfanyl)ethanone 

Relevant articles and documents

Efficient palladium-catalyzed aminocarbonylation of aryl iodides using palladium nanoparticles dispersed on siliceous mesocellular foam

A highly dispersed nanopalladium catalyst supported on mesocellular foam (MCF), was successfully used in the heterogeneous catalysis of aminocarbonylation reactions. During the preliminary evaluation of this catalyst it was discovered that the supported palladium nanoparticles exhibited a "release and catch" effect, meaning that a minor amount of the heterogeneous palladium became soluble and catalyzed the reaction, after which it re-deposited onto the support. It's catchy! An efficient palladium-catalyzed protocol for the aminocarbonylation of aryl iodides is reported in which the palladium immobilized on the amino-functionalized mesocellular foam (MCF) was found to operate through a "release and catch" mechanism (see scheme). A very low content of palladium was found in solution upon completion of the reaction and a variety of different aryl iodides were converted to the corresponding amides under mild conditions.

Deoxygenative hydroboration of primary, secondary, and tertiary amides: Catalyst-free synthesis of various substituted amines

Transformation of relatively less reactive functional groups under catalyst-free conditions is an interesting aspect and requires a typical protocol. Herein, we report the synthesis of various primary, secondary, and tertiary amines through hydroboration of amides using pinacolborane under catalyst-free and solvent-free conditions. The deoxygenative hydroboration of primary and secondary amides proceeded with excellent conversions. The comparatively less reactive tertiary amides were also converted to the corresponding N,N-diamines in moderate yields under catalyst-free conditions, although alcohols were obtained as a minor product.

Rhoda-Electrocatalyzed Bimetallic C?H Oxygenation by Weak O-Coordination

Rhodium-electrocatalyzed arene C?H oxygenation by weakly O-coordinating amides and ketones have been established by bimetallic electrocatalysis. Likewise, diverse dihydrooxazinones were selectively accessed by the judicious choice of current, enabling twofold C?H functionalization. Detailed mechanistic studies by experiment, mass spectroscopy and cyclovoltammetric analysis provided support for an unprecedented electrooxidation-induced C?H activation by a bimetallic rhodium catalysis manifold.