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Usage

Uses

Used in Pharmaceutical Industry:
N-isopropylcyclopropanamine is used as a reactant in the reductive aminations of carbonyl compounds with borohydride and borane reducing agents. This application is particularly relevant in the synthesis of complex organic molecules, including those with pharmaceutical importance. The reductive amination process allows for the formation of various amines, which are essential building blocks in the development of new drugs and therapeutic agents.
Used in Chemical Synthesis:
In the field of chemical synthesis, N-isopropylcyclopropanamine is utilized as a key reactant for the preparation of a wide range of organic compounds. Its unique structure enables it to participate in various chemical transformations, such as reductive amination, which can lead to the formation of diverse chemical products with potential applications in various industries.
Used in Research and Development:
N-isopropylcyclopropanamine is also employed in research and development settings, where it is used to explore new chemical reactions and develop innovative synthetic methods. Its reactivity and structural features make it a valuable tool for chemists working on the design and synthesis of novel organic compounds with potential applications in various fields, such as materials science, pharmaceuticals, and agrochemicals.

Upstream product

• 246257-63-6 cyclopropylisopropylamine hydrochloride 
• 925-90-6 ethylmagnesium bromide 
• 246257-65-8 cyclopropylisopropylformamide 
• 75-26-3 isopropyl bromide 
• 765-30-0 Cyclopropylamine 

Relevant academic research and scientific papers

Radical cations of trialkylamines: ESR spectra and structures

Novel syntheses of cyclopropyldiisopropylamine (15), di-tert- butylcyclopropylamine (16), dicyclopropylisopropylamine (17), and tricyclopropylamine (18) are described. Hyperfine data were determined by ESR spectroscopy for the radical cations of these trialkylamines, as well as for those of ethyldiisopropylamine (10), diisopropyl-n-propylamine (11), dicyclohexylethylamine (12), diisopropyl-3-pentylamine (14), and 1- azabicyclo[3.3.3]undecane (manxine; 27). The radical cation of triisopropylamine (13) was reexamined under conditions of improved spectral resolution. Coupling constants of the 14N nucleus and the β-protons in the radical cations of 18 trialkylamines provide reliable information about the geometries of these species, which are confirmed by theoretical calculations. With the exception of a few oligocyclic amines, for which flattening is impaired by the rigid molecular framework, all of the radical cations should be planar. Correlation between the observed coupling constants of the β- protons and the calculated 2 θ> values of the dihedral angle θ, defining the conformation of the alkyl substituent or the azacycloalkane, is verified. Upon oxidation, striking changes occur for those amines that have cyclopropyl substituents, because of the tendency of these groups to assume a perpendicular conformation in the neutral amines and a bisected orientation in the corresponding radical cations.

Kinetic Applications of Electron Paramagnetic Resonance Spectroscopy. 35. The Search for a Dialkylaminyl Rearrangement. Ring Opening of N-Cyclobutyl-N-n-propylaminyl

A search for a dialkylaminyl radical which rearranges at a rate suitable for study by kinetic EPR spectroscopy has shown that cyclobutyl-n-propylaminyl is such a species.This radical undergoes ring opening, and the rate constant for this process can be represented by log (kr/s-1) = (12.8+/-1.5) - (10.5+/-1.5)/θ, where θ = 2.3RT kcal/mol.