73148-15-9

Basic information

• Product Name: 6,7-dichloro-3-methyl-3,4-dihydroquinoxalin-2(1H)-one
• Synonyms: 6,7-dichloro-3-methyl-3,4-dihydroquinoxalin-2(1H)-one;6,7-Dichloro-3-Methyl-quinoxalin-2-ol
• CAS NO: 73148-15-9
• Molecular Formula: C₉H₆Cl₂N₂O
• Molecular Weight: 231.081
• Mol File: 73148-15-9.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 399°C at 760 mmHg
• Flash Point: 195.1°C
• Appearance: /
• Density: 1.581 g/cm³
• Vapor Pressure: 1.42E-06mmHg at 25°C
• Refractive Index: 1.567
• CAS DataBase Reference: 6,7-dichloro-3-methyl-3,4-dihydroquinoxalin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-dichloro-3-methyl-3,4-dihydroquinoxalin-2(1H)-one(73148-15-9)
• EPA Substance Registry System: 6,7-dichloro-3-methyl-3,4-dihydroquinoxalin-2(1H)-one(73148-15-9)

Safety Data

• Hazardous Substances Data: 73148-15-9(Hazardous Substances Data)

Usage

General Description

6,7-dichloro-3-methyl-3,4-dihydroquinoxalin-2(1H)-one is a chemical compound with the molecular formula C9H8Cl2N2O. It is a substituted quinoxaline derivative, which is a class of heterocyclic compounds. This chemical is commonly used in the pharmaceutical industry for its potential biological activities and medicinal properties. It has been studied for its potential use as an anti-microbial and anti-cancer agent, and is also being investigated for its potential as an anti-inflammatory and anti-malarial compound. Additionally, it has been used in research as a building block for the synthesis of other bioactive compounds. Its chemical structure and properties make it a valuable tool for drug discovery and development.

InChI:InChI=1/C9H8Cl2N2O/c1-4-9(14)13-8-3-6(11)5(10)2-7(8)12-4/h2-4,12H,1H3,(H,13,14)

Upstream product

• 5348-42-5 4,5-Dichloro-1,2-phenylenediamine 
• 600-22-6 pyruvic acid methyl ester 
• 2339-78-8 1,2-dichloro-4-fluoro-5-nitrobenzene 
• 127-17-3 2-oxo-propionic acid 
• 617-35-6 2-oxo-propionic acid ethyl ester 

Downstream Products

• 149366-37-0 6,7-dichloro-3-styrylquinoxaline-2(1H)-one 
• 216436-74-7 6,7-Dichloro-3-(3,5-diphenyl-furan-2-yl)-1H-quinoxalin-2-one 
• 216436-73-6 6,7-Dichloro-3-(4-oxo-2-phenyl-4-pyridin-4-yl-butyl)-1H-quinoxalin-2-one 
• 216436-75-8 6,7-Dichloro-3-(3-phenyl-5-pyridin-4-yl-furan-2-yl)-1H-quinoxalin-2-one 

Relevant articles and documents

Styryl-containing quinoxalinone derivatives and preparation method thereof

The invention belongs to the technical field of medicinal chemistry, and particularly relates to styryl-containing quinoxalinone derivatives and a preparation method thereof, and the structure of thesynthesized compound is shown as the following formula I

Citric acid: An efficient and green catalyst for rapid one pot synthesis of quinoxaline derivatives at room temperature

The condensation of o-phenylenediamines with 1,2-dicarbonyl compounds in the presence of citric acid afforded the corresponding quinoxaline derivatives in higher yields at room temperature in ethanol, and most of the reactions were completed in less than 1 min.

Revisiting the Hinsberg reaction: Facile and expeditious synthesis of 3-substituted quinoxalin-2(1H)-ones under catalyst-free conditions in water

Substituted benzene-1,2-diamine reacted with various α-keto esters at 50° under mild conditions for 15 min using H2O as reaction medium, providing a variety of 3-substituted quinoxalinone derivatives in excellent yields. The reaction was instantaneous, and products were isolated by simple filtration.